Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria.
Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria.
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DOI：
10.3389/fphar.2022.873374
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发表时间：
2022
影响因子：
5.6
通讯作者：
Liu, Xiaoye
中科院分区：
文献类型：
--
作者：
Song, Lianyu;Hu, Xin;Ren, Xiaomin;Liu, Jing;Liu, Xiaoye
关键词：
多药耐药（MDR）细菌感染的传播日益增加，危及全球公共卫生。如何开发出有效的抗菌药物来对抗耐药菌已成为解决耐药危机的迫切需求之一。具有多靶点抗菌作用的中药是治疗细菌耐药性的有效途径。基于整体性和辨证分型的创新理念，中医药在抗菌治疗中的应用令人鼓舞。近年来，清热类中药黄酮类化合物在耐药菌治疗中的研究进展显示了其潜在的应用价值。本文就黄酮类化合物的抗菌作用机制进行综述。此外，我们还概述了类黄酮化合物的作用靶点，并根据其作用方式将其分为直接作用抗菌化合物（DAC）和宿主作用抗菌化合物（HAC）。我们还讨论了黄酮类化合物的相关官能团，并强调了最近对各种耐药细菌的药理活性，为临床感染提供候选药物。
The increasing dissemination of multidrug resistant (MDR) bacterial infections endangers global public health. How to develop effective antibacterial agents against resistant bacteria is becoming one of the most urgent demands to solve the drug resistance crisis. Traditional Chinese medicine (TCM) with multi-target antibacterial actions are emerging as an effective way to combat the antibacterial resistance. Based on the innovative concept of organic wholeness and syndrome differentiation, TCM use in antibacterial therapies is encouraging. Herein, advances on flavonoid compounds of heat-clearing Chinese medicine exhibit their potential for the therapy of resistant bacteria. In this review, we focus on the antibacterial modes of herbal flavonoids. Additionally, we overview the targets of flavonoid compounds and divide them into direct-acting antibacterial compounds (DACs) and host-acting antibacterial compounds (HACs) based on their modes of action. We also discuss the associated functional groups of flavonoid compounds and highlight recent pharmacological activities against diverse resistant bacteria to provide the candidate drugs for the clinical infection.
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影响因子：
3.7
作者：
Aparna V;Dineshkumar K;Mohanalakshmi N;Velmurugan D;Hopper W
通讯作者：
Hopper W
影响因子：
3.7
作者：
Brown, Adam R.;Ettefagh, Keivan A.;Cech, Nadja B.
通讯作者：
Cech, Nadja B.
影响因子：
5.5
作者：
Cavalcante de Araujo, Daniel Rodrigo;da Silva, Tulio Diego;dos Santos Correia, Maria Tereza
通讯作者：
dos Santos Correia, Maria Tereza
DOI：
10.3390/molecules22040608
发表时间：
2017-04-10
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Echeverría J;Opazo J;Mendoza L;Urzúa A;Wilkens M
通讯作者：
Wilkens M
影响因子：
3.8
作者：
Kamdi, Sandesh P.;Raval, Amit;Nakhate, Kartik T.
通讯作者：
Nakhate, Kartik T.