Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals
Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals
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DOI：
10.1139/y07-030
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发表时间：
2007-09-01
影响因子：
2.1
通讯作者：
Vuksan, Vladimir
中科院分区：
文献类型：
--
作者：
Dascalu, Anamaria;Sievenpiper, John L.;Vuksan, Vladimir
有证据表明，西洋参根的降血糖作用可能是批次依赖性的。因此，我们评估了5根批次，安大略省种植的西洋参的代表，餐后血糖和胰岛素指数的影响。12名健康受试者（5男，7女），平均SE年龄26.5 +/- 2岁，体重指数23.96 +/- 3.41 kg/m2，空腹血糖4.77 +/- 0.04 mmol/L，被分配食用来自5个农场（A-E）的9 g西洋参，在5次单独访视中随机给药，在第六次和最后一次访视期间进行了水控制。在2小时75克口服葡萄糖耐量试验前40分钟服用治疗药物。在基线、试验前和试验期间测量血糖和胰岛素。与对照相比，批次A和C分别使葡萄糖增量曲线下面积（IAUC）降低35.2%（156与240 mmol中心点min/L）和32.6%（162与240 mmol·min/L）。批次A、C和E分别使峰值葡萄糖增量降低1.3、1.2和1.1 mmol/L。批次C使胰岛素IAUC降低27.7%（15.8与21.8 nmol-min/L）。对葡萄糖和胰岛素参数的影响在人参治疗中没有差异。与对照组相比，5种人参治疗的平均值使餐后葡萄糖峰值降低1.0 mmol/L，葡萄糖IAUC降低27.7%（173与240 mmol-min/L），胰岛素IAUC降低23.8%（16.6与21.8 nmol中心点min/L）。(All结果统计学显著性为p < 0.05）。西洋参降低餐后血糖和胰岛素血症;然而，40%的批次没有降低血糖与预期的幅度，无论其皂苷组成。
Evidence indicates that the glycemia-lowering effect of American ginseng root may be batch dependent. We therefore evaluated the effect of 5 root batches, representative of Ontario-grown American ginseng, on postprandial glucose and insulin indices. Twelve healthy subjects (5 male, 7 female), mean SE age 26.5 +/- 2 years, body mass index 23.96 +/- 3.41 kg/m(2), fasting blood glucose 4.77 +/- 0.04 mmol/L, were assigned to consume 9 g of American ginseng from 5 farms (A-E), administered in randomized sequence on 5 separate visits, and a water-control during the 6th and last visit. Treatments were consumed 40 min before a 2-hour 75-gram oral glucose tolerance test. Plasma glucose and insulin were measured at baseline, before, and during the test. Compared with control, batches A and C reduced glucose incremental area under the curve (IAUC) by 35.2% (156 vs. 240 mmol center dot min/L) and 32.6% (162 vs. 240 mmol-min/L), respectively. Batches A, C, and E reduced incremental peak glucose by 1.3, 1.2, and 1.1 mmol/L, respectively. Batch C reduced the insulin IAUC by 27.7% (15.8 vs. 21.8 nmol-min/L). Effects on glucose and insulin parameters were not different across ginseng treatments. The mean of the 5 ginseng treatments reduced peak postprandial glucose by 1.0 mmol/L, glucose IAUC by 27.7% (173 vs. 240 mmol-min/L), and insulin IAUC by 23.8% (16.6 vs. 21.8 nmol center dot min/L) relative to control. (All results statistically significant at p < 0.05.) American ginseng decreased postprandial glycemia and insulinemia; however, 40% of the batches did not reduce glycemia with the anticipated magnitude, irrespective of their saponin composition.