Differential expression of the zinc finger gene Zfp105 during spermatogenesis
Differential expression of the zinc finger gene Zfp105 during spermatogenesis
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DOI：
10.1007/s003359900859
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发表时间：
1998-09-01
期刊：
影响因子：
2.5
通讯作者：
Ackerman, SL
中科院分区：
文献类型：
--
作者：
Przyborski, SA;Knowles, BB;Ackerman, SL
我们报道了人类ZNF35锌指基因的小鼠同源基因Zfp105的分离。Zfp105和ZNF35在蛋白质和核苷酸水平上高度保守，Zfp105定位于小鼠染色体(Chr)9的一个区域，该区域与包含ZNF35的人类区域同源。Zpf105在睾丸中高表达，尤其在粗线型精母细胞和圆形精细胞中表达较高。讨论了该基因产物在维持生殖细胞有序分化过程中的可能作用。
We report the isolation of Zfp105, the mouse homolog of the human ZNF35 zinc finger gene. Zfp105 and ZNF35 are highly conserved at the protein and nucleotide level, and Zfp105 maps to a region of mouse Chromosome (Chr) 9 that is homologous to the human region containing ZNF35. Zpf105 is highly expressed in the testis, especially in pachytene spermatocytes and round spermatids. The possible role of this gene product in maintaining an ordered germ cell differentiation process is discussed.