Recent insights and novel bioinformatics tools to understand the role of microRNAs binding to 5' untranslated region.
Recent insights and novel bioinformatics tools to understand the role of microRNAs binding to 5' untranslated region.
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DOI：
10.3390/ijms14010480
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发表时间：
2012-12-27
影响因子：
5.6
通讯作者：
Masotti A
中科院分区：
文献类型：
--
作者：
Da Sacco L;Masotti A
MicroRNAs （miRNAs）是一种小的非编码rna，通过结合特定mrna的3 ‘非翻译区（3 ’ utr）来调节基因表达。mirna是转录后调控因子，决定翻译过程的抑制或mRNA靶标的降解。最近，另一种miRNA介导的翻译调控（抑制或激活）涉及miRNA与靶基因5'UTR的结合。可能的相互作用和作用机制已经在许多工作中被报道，我们在这里回顾。此外，我们还讨论了预测5'UTR中miRNA结合位点的可用生物信息学工具和收集这些信息的公共数据库。
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the binding of the 3′ untranslated region (3′UTR) of specific mRNAs. MiRNAs are post-transcriptional regulators and determine the repression of translation processes or the degradation of mRNA targets. Recently, another kind of miRNA-mediated regulation of translation (repression or activation) involving the binding of miRNA to the 5′UTR of target gene has been reported. The possible interactions and the mechanism of action have been reported in many works that we reviewed here. Moreover, we discussed also the available bioinformatics tools for predicting the miRNA binding sites in the 5′UTR and public databases collecting this information.
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