Butanol is superior to water for performing positron emission tomography activation studies.
Butanol is superior to water for performing positron emission tomography activation studies.
复制标题
在进行正电子发射断层扫描激活研究方面，丁醇优于水。
DOI：
10.1097/00004647-199909000-00005
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Goodman,MM
中科院分区：
文献类型：
--
作者：
Votaw,JR;Henry,TR;Shoup,TM;Hoffman,JM;Woodard,JL;Goodman,MM
[15 O]丁醇已被证明上级[15 O]水用于正电子发射断层扫描测量脑血流量。这项工作表明，它也是上级进行活化研究。在三种条件下收集数据：视觉对抗动物命名任务，无意义的数字大小歧视，和非视觉暗室控制任务。时间-活性曲线（TAC）获得已知被激活的对抗命名任务的区域，以比较绝对摄取和两种示踪剂的不同动力学。此外，tstatistic地图计算10名受试者的数据为两种示踪剂和比较的变化幅度和激活区域的大小。两种示踪剂在全脑TAC中的峰值摄取相似。对于所有区域和条件，[15 O]丁醇的洗脱率比[15 O]水的洗脱率高41%。在阈值为0时，[15 O]水和[15 O]丁醇的百分比差异（非归一化）和tstatistic（全局归一化）图像几乎相同，表明两种示踪剂测量的性质相同。[15 O]丁醇参数图像显示的阈值为|不|= 5看起来类似于[15 O]水参数图显示的阈值为|不|= 4，这与[15 O]丁醇图像中的统计值通常较大的观察结果一致。当从6名受试者的任何子集创建[15 O]丁醇参数图和从所有10名受试者创建[15 O]水参数图时，统计值相等。需要用[15 O]丁醇研究的受试者较少，以达到与[15 O]水基研究相同的统计功效。
[15O]Butanol has been shown to be superior to [15O]water for measuring cerebral blood flow with positron emission tomography. This work demonstrates that it is also superior for performing activation studies. Data were collected under three conditions: a visual confrontation animal-naming task, nonsense figure size discrimination, and a nonvisual darkroom control task. Time–activity curves (TAC) were obtained for regions known to be activated by the confrontation naming task to compare absolute uptake and the different kinetics of the two tracers. Also,tstatistic maps were calculated from the data of 10 subjects for both tracers and compared for magnitude of change and size of activated regions. Peak uptake in the whole-brain TAC were similar for the two tracers. For all regions and conditions, the washout rate of [15O]butanol was 41% greater than that of [15O]water. At a threshold of 0, the [15O]water and [15O]butanol percent difference (nonnormalized) andtstatistic (global normalization) images are nearly identical, indicating that the same property is being measured with both tracers. The [15O]butanol parametric images displayed at a threshold of |t| = 5 look similar to the [15O]water parametric maps displayed at a threshold of |t| = 4, which is consistent with the observation thattstatistic values in [15O]butanol images are generally greater. Thetstatistic values were equal when the [15O]butanol parametric map was created from any subset of 6 subjects and the [15O]water parametric map was created from all 10 subjects. Fewer subjects need to be studied with [15O]butanol to reach the same statistical power as an [15O]water-based study.