Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2.
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2.
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DOI：
10.12688/wellcomeopenres.16661.1
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发表时间：
2021-01-01
影响因子：
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通讯作者：
Kraemer, Moritz U G
中科院分区：
文献类型：
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作者：
O'Toole, Aine;Hill, Verity;Kraemer, Moritz U G
2020年底，报告了两个具有生物学意义的突变的严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）基因不同的集群，一个在英国，一个在南非。利用常规监测、基因组测序和国际旅行的数据，我们追踪了B.1.1.7和B.1.351（变异体501 Y-V2）的国际传播。我们通过分别纳入首次报告该谱系的地点（伦敦和南非）的乘客量来解释基因组监测工作中的潜在偏差。使用软件工具grinch（调查新型冠状病毒单倍型的全球报告），我们通过自动每日报告跟踪关注谱系的国际传播，此外，我们建立了一个自定义跟踪网站（cov-lineages.org/global_report.html），该网站托管该每日报告，并将继续包括检测到的新型SARS-CoV-2关注谱系。
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.