Impact of body mass index on IVF and CS outcome: a retrospective study
Impact of body mass index on IVF and CS outcome: a retrospective study
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DOI：
10.1016/s1472-6483(10)60142-3
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发表时间：
2008-06-01
影响因子：
4
通讯作者：
Arici, Aydin
中科院分区：
文献类型：
--
作者：
Matalliotakis, Ioannis;Cakmak, Hakan;Arici, Aydin
一组140名体重指数（BMI）24 kg /m2的妇女，在291个周期中，关于卵巢刺激的持续时间和促性腺激素的剂量，收集的卵母细胞数量，卵裂率和着床率，临床妊娠率，流产率和分娩率。BMI > 24 kg/m2的患者显示刺激后卵泡数量显著减少（P = 0.01），使用促性腺激素的安瓿数量相对增加（P = 0.03），收集的卵子数量减少（P = 0.05）。BMI > 24 kg/m2组第1、2和3天的平均胚胎数显著低于BMI > 24 kg/m2组（P < 0.001）。两组临床妊娠率和流产率无显著性差异。尽管BMI > 24 kg/m2的女性的反应较低，但每次取出的分娩率没有差异（24.6%对24.8%）。这些结果表明，BMI升高的女性的刺激反应较低，但对IVF结果没有不良影响。然而，在健康方面，建议BMI高的患者在IVF治疗前减轻体重。
A group of 140 women with a body mass index (BMI) 24 kg /m(2) in 291 cycles, with respect to duration of ovarian stimulation and dose of gonadotrophin, number of oocytes collected, cleavage and implantation rate, clinical pregnancy, miscarriage and delivery rates. Patients with a BMI > 24 kg/m(2) demonstrated a significant decrease in the number of follicles after stimulation (P = 0.01), a comparative increase in the number ampoules of gonadotrophin used (P = 0.03) and a lower number of eggs collected (P = 0.05). The mean number of embryos on days 1, 2 and 3 was significantly lower in the group with BMI > 24 kg/m(2) (P < 0.001). No significant difference was found in clinical pregnancy and miscarriage rates between the two groups. In spite of the lower response in women with BMI > 24 kg/m(2), the delivery rate per retrieval was not different (24.6 versus 24.8%). These results indicate a lower stimulation response in women with elevated BMI, but no adverse effect on IVF outcome. In relation to wellbeing, however, it is recommended that patients with a high BMI reduce their weight before IVF treatment.