Health and exposures of United Kingdom Gulf war veterans. Part II: The relation of health to exposure
Health and exposures of United Kingdom Gulf war veterans. Part II: The relation of health to exposure
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DOI：
10.1136/oem.58.5.299
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发表时间：
2001-05-01
影响因子：
4.9
通讯作者：
Macfarlane, GJ
中科院分区：
文献类型：
--
作者：
Cherry, N;Creed, F;Macfarlane, GJ
目的-调查是否，在人员谁与英国部队在海湾战争中，自我报告的风险与症状的方式是一致的，具体的，和credible.Methods-Responses症状和暴露问卷，完成7年或更长的时间后，从7971个主题部署在海湾地区，从两个暴露队列，在一项总有效率为85.5%的研究中，暴露被认为是在三个组中，那些控制以外的受试者，预防的使用，和敏感性指标。在一系列多元回归分析中，从症状问卷中得出的健康指数与这三个组中14个暴露的报告相关，以允许混淆。暴露的投诉广泛的疼痛和周围神经病变的症状的关系进行了检查logistic regression.Results-Consistent，但暴露和健康影响之间的相关性弱，发现在独立分析的两个（主要和验证）队列。三个曝光以外的控制的主题，接种的数量，处理农药的天数，以及暴露于烟雾从石油火灾的天数，是一贯的和独立的严重程度。接种次数也与皮肤和肌肉骨骼疾病相关症状的加权因子得分较高相关。处理农药的天数特别与神经因素的分数和与中毒性神经病一致的症状有关。结论-暴露与健康不良之间的关系一般较弱。一致的，具体的，和可信的关系，未经进一步调查，发现健康指数和两个曝光，接种和处理农药的天数报告之间。
Objectives-To investigate whether, in personnel who served with the United Kingdom forces in the Gulf war, self reported exposures were related to symptoms in a way that was consistent, specific, and credible.Methods-Responses to symptom and exposure questionnaires, completed 7 or more years after the war, were collected from 7971 subjects deployed in the Gulf, from two exposed cohorts, in a study with an overall response rate of 85.5%. Exposures were considered in three groups, those outside the control of the subjects, the use of prophylaxis, and indicators of susceptibility. Health indices derived from symptom questionnaires were related to reports of 14 exposures in these three groups in a series of multiple regression analyses to allow for confounding. The relation of exposure to complaints of widespread pain and to symptoms suggesting peripheral neuropathy were examined by logistic regression.Results-Consistent but weak correlations between exposures and with health effects were found in independent analyses of the two (main and validation) cohorts. Three exposures outside the control of the subject, the number of inoculations, the number of days handling pesticides, and the days exposed to smoke from oil fires, were consistently and independently related to severity. The number of inoculations was also associated with higher scores on a factor weighted on symptoms associated with skin and musculoskeletal complaints. The number of days handling pesticides related particularly to scores on a neurological factor and to symptoms consistent with toxic neuropathy. Conclusion-The relations between exposures and ill health were generally weak. Consistent, specific, and credible relations, warranting further investigation, were found between health indices and two exposures, the reported number of inoculations and days handling pesticides.