Genetic and Environmental interactions contribute to immune variation in rewilded mice.
Genetic and Environmental interactions contribute to immune variation in rewilded mice.
复制标题
遗传和环境的相互作用导致野化小鼠的免疫变异。
DOI：
10.1101/2023.03.17.533121
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kor
中科院分区：
文献类型：
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作者：
Oyesola,Oyebola;Downie,AlexanderE;Howard,Nina;Barre,RamyaS;Kiwanuka,Kasalina;Zaldana,Kimberly;Chen,Ying-Han;Menezes,Arthur;Lee,SooChing;Devlin,Joseph;Mondragón-Palomino,Octavio;Souza,CamilaOliveiraSilva;Herrmann,Christin;Kor
遗传和环境对个体间免疫反应变异的相对和协同作用仍不清楚，尽管它对理解进化生物学和医学都有影响。在这里，我们量化的基因型和环境对免疫性状的相互作用的影响，通过调查三个近交系小鼠品系rewilded在室外封闭和感染寄生虫，鞭虫。细胞因子反应异质性主要由基因型驱动，而细胞组成异质性则由基因型和环境之间的相互作用形成。值得注意的是，实验室条件下的遗传差异可以在野化后减少，并且T细胞标记物的变化更多地由遗传驱动，而B细胞标记物更多地由环境驱动。重要的是，蠕虫负担的变化与免疫变异的测量以及遗传和环境有关。这些结果表明，非遗传影响与遗传因素相互作用，形成免疫变异，协同影响防御机制的部署和进化。
The relative and synergistic contributions of genetics and environment to inter-individual immune response variation remain unclear, despite its implications for understanding both evolutionary biology and medicine. Here, we quantify interactive effects of genotype and environment on immune traits by investigating three inbred mouse strains rewilded in an outdoor enclosure and infected with the parasite, Trichuris muris. Whereas cytokine response heterogeneity was primarily driven by genotype, cellular composition heterogeneity was shaped by interactions between genotype and environment. Notably, genetic differences under laboratory conditions can be decreased following rewilding, and variation in T cell markers are more driven by genetics, whereas B cell markers are driven more by environment. Importantly, variation in worm burden is associated with measures of immune variation, as well as genetics and environment. These results indicate that nonheritable influences interact with genetic factors to shape immune variation, with synergistic impacts on the deployment and evolution of defense mechanisms.