Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease
Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease
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DOI：
10.1016/j.ijcard.2019.05.045
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发表时间：
2019-10-01
影响因子：
3.5
通讯作者：
Hasegawa, Shunji
中科院分区：
文献类型：
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作者：
Ohnishi, Yuji;Yasudo, Hiroki;Hasegawa, Shunji
背景：川崎病（Kawasaki disease， KD）是一种病因不明的急性自限性血管炎，患者的主要并发症是冠状动脉病变（CALs）。内皮糖萼是覆盖在内皮细胞表面的网状膜。本研究旨在评估血清糖萼成分作为预测KD患者CALs发病的生物标志物的临床应用价值。方法：70例完全型KD患者，发热对照组（FC） 18例，发热对照组（AC） 15例。回顾性分析病历中的医学、人口统计学、超声心动图和实验室数据。在静脉注射免疫球蛋白（IVIG）治疗前的急性期、IVIG治疗后立即、亚急性期和恢复期出院时测定血清syndecan-1和透明质酸水平。结果：在所有三个阶段，KD组血清syndecan-1和透明质酸水平均高于AC和FC组。此外，这些水平在有和没有发生钙的KD患者之间进行了比较。有CALs的KD患者急性期血清syndecan-1和透明质酸水平明显高于无CALs的KD患者。血清透明质酸，而不是syndecan-1，通过多重逻辑分析被确定为预测CALs的最重要参数。结论：循环syndecan-1和透明质酸可作为预测KD患者CALs发展的有用生物标志物。(C) 2019 Elsevier B.V.版权所有
Background: Kawasaki disease (KD) is acute and self-limited vasculitis caused by unknown origin, and the critical complication in KD patients is coronary artery lesions (CALs). The endothelial glycocalyx is a network of membranes luminally covering the endothelium. This study aimed to evaluate the clinical utility of serum glycocalyx components as biomarkers of predicting the onset CALs in KD.Methods: Seventy subjects with complete type KD, 18 subjects as febrile control (FC), and 15 subjects as afebrile controls (AC) were enrolled. Medical, demographic, echocardiography, and laboratory data fromthe medical records were retrospectively analyzed. Serum syndecan-1 and hyaluronan levels prior to intravenous immunoglobulin (IVIG) therapy were measured at the acute phase, immediately after IVIG, the subacute phase, and the time of discharge at the convalescent phase.Results: Serumsyndecan-1 and hyaluronan levels were higher in the KD group than in the AC and FC groups at all three phases. Further, these levels were compared between KD patients with and without the development of CALs. Serum syndecan-1 and hyaluronan levels at the acute phase were significantly elevated in KD patients with the CALs than in those without CALs. Serum hyaluronan, not syndecan-1, was determined as the most contributory parameter to predict CALs by a multiple logistic analysis.Conclusions: Circulating syndecan-1 and hyaluronan can be useful biomarkers to predict the development of CALs in KD. (C) 2019 Elsevier B.V. All rights reserved.