An update on the blood vessel in migraine.
An update on the blood vessel in migraine.
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DOI：
10.1097/wco.0b013e32833821c1
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发表时间：
2010-06
影响因子：
4.8
通讯作者：
Charles A
中科院分区：
文献类型：
--
作者：
Brennan KC;Charles A
颅血管被认为是偏头痛的病理生理学中不可或缺的参与者，但其感知的作用多年来一直受到许多讨论和争议。我们将讨论我们对偏头痛中颅内血管（主要是动脉）的科学理解的演变。最近的发展已经阐明了颅血管在三叉神经血管系统和皮质扩散性抑制中的作用。一个潜在的主题是血管活动和神经功能之间的密切关系，我们将强调血管除了输送血液之外的各种作用。我们的结论是，不能理解偏头痛，无论是从研究或临床的角度来看，如果不了解血管紊乱伴随it.Migraine伴随着显着紊乱的血管功能，可能是调查和治疗的重要目标。
The cranial blood vessel is considered an integral player in the pathophysiology of migraine, but its perceived role has been subject to much discussion and controversy over the years. We will discuss the evolution in our scientific understanding of cranial blood vessels (primarily arteries) in migraine. Recent developments have clarified the role of cranial blood vessels in the trigemino-vascular system and in cortical spreading depression. An underlying theme is the intimate relation between vascular activity and neural function, and we will emphasize the various roles of the blood vessel that go beyond delivering blood. We conclude that migraine cannot be understood, either from a research or clinical point of view, without an understanding of the vascular derangements that accompany it. Migraine is accompanied by significant derangements in vascular function that may represent important targets for investigation and treatment.