Multiple Myeloma in World Trade Center Responders: A Case Series
Multiple Myeloma in World Trade Center Responders: A Case Series
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DOI：
10.1097/jom.0b013e3181ad49c8
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发表时间：
2009-08-01
影响因子：
3.2
通讯作者：
Savitz, David A.
中科院分区：
文献类型：
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作者：
Moline, Jacqueline M.;Herbert, Robin;Savitz, David A.
目的：我们报告在世界贸易中心（WTC）医疗计划中登记的世界贸易中心（WTC）反应者中观察到的多发性骨髓瘤（MM）病例。方法：对可能确诊的MM病例进行分析。2001年9月11日和2007年9月10日，如果他们符合世界卫生组织和马约诊所的诊断标准，则确认应答者。结果：在28，252名已知性别和年龄的应答者中，观察到8例MM病例（预期6.8例）。其中4例病例是在诊断时年龄小于45岁的应答者中观察到的（预期为1.2例）。在45岁以上的缓解者中观察到MM病例略有不足（观察到4例，预期5.6例）。结论：在该病例系列中，我们观察到45岁以下WTC应答者中MM病例的数量异常。这一发现强调了在这一高度暴露人群中保持对癌症和其他新兴疾病监测的重要性。（J Occup Environ Med.2009;51：896-902）
Objectives: We report on cases of multiple myeloma (MM) observed in World Trade Center (WTC) responders registered in the WTC Medical Program. Methods: Possible cases of MM diagnosed between. September 11, 2001, and September 10, 2007, in responders were confirmed if they met the World Health Organization and Mayo Clinic diagnostic criteria. Results: Among 28,252 responders of known sex and age, eight cases of MM were observed (6.8 expected.). Four of these cases were observed in responders younger than 45 years at the time of diagnosis (1.2 expected). A slight deficit of MM cases was observed in responders older than 45 years (4 observed, 5.6 expected). Conclusion: In this case series, we observe an unusual number of MM cases in WTC responders under 45 years. This finding underscores the importance of maintaining surveillance for cancer and other emerging diseases in this highly exposed population. (J Occup Environ Med. 2009;51:896-902)