Noninvasive Associative Plasticity Induction in a Corticocortical Pathway of the Human Brain
Noninvasive Associative Plasticity Induction in a Corticocortical Pathway of the Human Brain
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DOI：
10.1523/jneurosci.1513-11.2011
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发表时间：
2011-11-30
影响因子：
5.3
通讯作者：
Rushworth, Matthew F. S.
中科院分区：
文献类型：
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作者：
Buch, Ethan R.;Johnen, Vanessa M.;Rushworth, Matthew F. S.
突触前和突触后活动的一致配对选择性地加强突触连接，这是皮层可塑性的关键机制。使用配对关联经颅磁刺激（TMS），我们证明了选择性增强的生理连接之间的两个人脑区域，腹侧运动前皮层（PMV）和初级运动皮层（M1）后，重复配对脉冲TMS的PMV和M1。这种效应在解剖学上是特异性的：成对刺激前辅助运动区和M1不会引起PMv-M1通路连接的变化。这种效应依赖于刺激顺序：在M1之前重复刺激PMv导致PMv-M1通路的加强，而在PMv之前重复刺激M1则减弱了PMv-M1通路的强度。表达的变化的途径取决于受试者的认知状态在测试时：当受试者在休息时进行测试，配对PMv-M1刺激导致增加的抑制影响PMv超过M1，但当受试者进行测试，而从事视觉任务，PMv-M1刺激导致增加的促进影响PMv超过M1。可塑性发展迅速，持续至少1小时，并开始逆转干预后3小时。
Coincident pairing of presynaptic and postsynaptic activity selectively strengthens synaptic connections, a key mechanism underlying cortical plasticity. Using paired associative transcranial magnetic stimulation (TMS), we demonstrate selective potentiation of physiological connectivity between two human brain regions, ventral premotor cortex (PMv) and primary motor cortex (M1) after repeated paired-pulse TMS of PMv and M1. The effect was anatomically specific: paired stimulation of the presupplementary motor area and M1 did not induce changes in PMv-M1 pathway connectivity. The effect was dependent on stimulation order: repeated stimulation of PMv before M1 led to strengthening of the PMv-M1 pathway, while repeated stimulation of M1 before PMv diminished the strength of the PMv-M1 pathway. The expression of the change in the pathway depended on the cognitive state of the subject at the time of testing: when the subject was tested at rest, paired PMv-M1 stimulation led to an increased inhibitory influence of PMv over M1, but when the subject was tested while engaged in a visuomotor task, PMv-M1 stimulation led to an increased facilitatory influence of PMv over M1. Plasticity evolved rapidly, lasted for at least 1 h, and began to reverse 3 h after intervention.