Human Leukocyte Antigen Crossmatch Testing is Important for Liver Retransplantation
Human Leukocyte Antigen Crossmatch Testing is Important for Liver Retransplantation
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DOI：
10.1002/lt.21981
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发表时间：
2010-03-01
影响因子：
4.6
通讯作者：
Terasaki, Paul I.
中科院分区：
文献类型：
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作者：
Goh, Angeline;Scalamogna, Mario;Terasaki, Paul I.
虽然人类白细胞抗原（HLA）交叉配型通常被认为是不必要的肝移植（LT），我们提供的证据表明，再次移植，在Luminex平台上使用单抗原珠对139例接受已故供体肝脏的再次移植患者的血清进行回顾性分析，以检测HLA抗体。每位患者接受至少2次移植，并随访至少6个月。从第二次LT开始，如果患者进行了第三次LT或死亡，则认为第二次LT失败。第二次LT的生存期是从第二次LT的日期到第三次LT或死亡的日期计算的。我们的研究队列包括118名成人患者（≥ 18岁）以及21名儿科患者（
Although human leukocyte antigen (HLA) crossmatching is often thought to be unnecessary for liver transplants (LTs), we provide evidence that for retransplants, it is essential Sera from 139 retransplant patients who had received livers from deceased donors were retrospectively analyzed with single antigen beads on a Luminex platform for HLA antibodies Each patient received at least 2 transplants and was followed up for at least 6 months from the second LT, which was deemed to have failed if the patient had a third LT or died Second LT survival was calculated from the date of the second LT to the date of the third LT or death Our study cohort consisted of 118 adult patients (>= 18 years old) as well as 21 pediatric patients (