Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system
Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system
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DOI：
10.1016/s0896-6273(01)00474-3
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发表时间：
2001-10-25
期刊：
影响因子：
16.2
通讯作者：
Zipursky, SL
中科院分区：
文献类型：
--
作者：
Clandinin, TR;Lee, CH;Zipursky, SL
果蝇复眼中不同类型的感光神经元（R细胞）连接到视叶中的特定靶点。使用行为筛选，我们确定LAR，受体酪氨酸磷酸酶，作为所需的R细胞靶向特异性。在LAR突变嵌合体眼中，R1-R6细胞正确地靶向板层，但未能选择正确的靶神经元模式。虽然突变的R7轴突最初投射到髓质的正确层，但它们缩回到不适当的层。使用单细胞镶嵌，我们证明，LAR控制靶向R1-R6和R7在细胞自主的方式。LAR突变体R细胞的表型与N-钙粘蛋白突变体中观察到的表型惊人相似。
Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye connect to specific targets in the optic lobe. Using a behavioral screen, we identified LAR, a receptor tyrosine phosphatase, as being required for R cell target specificity. In LAR mutant mosaic eyes, R1-R6 cells target to the lamina correctly, but fail to choose the correct pattern of target neurons. Although mutant R7 axons initially project to the correct layer of the medulla, they retract into inappropriate layers. Using single cell mosaics, we demonstrate that LAR controls targeting of R1-R6 and R7 in a cell-autonomous fashion. The phenotypes of LAR mutant R cells are strikingly similar to those seen in N-cadherin mutants.