Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor
Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor
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DOI：
10.1117/1.jbo.25.6.063803
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发表时间：
2020-06-01
影响因子：
3.5
通讯作者：
Awazu, Kunio
中科院分区：
文献类型：
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作者：
Izumoto, Atsuki;Nishimura, Takahiro;Awazu, Kunio
间质光动力疗法（iPDT）与5-氨基乙酰丙酸（ALA）是一种可能的替代治疗恶性脑肿瘤。然而，在临床应用之前，还需要进一步的评估。ALA-iPDT中生物物理过程的计算模拟可以为理解治疗结果提供定量工具，这取决于与临床治疗条件相关的各种变量。我们提出了一种临床模拟方法ALA-iPDT恶性脑肿瘤使用单线态氧（O-1（2））模型和O-1（2）阈值诱导细胞死亡。在这种方法中，产生的O-1（2）的量是使用光敏剂光漂白系数和O-1（2）量子产率计算的，这在以前的几项研究中已经测量过。使用临床磁共振成像数据的模拟结果表明，需要指定圆柱形光扩散器的插入位置和光通量水平。数值脑肿瘤模型的详细分析表明，ALA-iPDT治疗结果取决于光漂白和阈值的组合。这些结果表明，个体医疗程序，包括治疗前计划和治疗监测，将大大受益于ALA-iPDT结果的模拟。(C)作者。由SPIE在知识共享署名4.0未移植许可下发布。
Interstitial photodynamic therapy (iPDT) with 5-aminolevulinic acid (ALA) is a possible alternative treatment for malignant brain tumors. Further evaluation is, however, required before it can be clinically applied. Computational simulation of the photophysical process in ALA-iPDT can offer a quantitative tool for understanding treatment outcomes, which depend on various variables related to clinical treatment conditions. We propose a clinical simulation method of ALA-iPDT for malignant brain tumors using a singlet oxygen (O-1(2)) model and O-1(2) threshold to induce cell death. In this method, the amount of O-1(2) generated is calculated using a photosensitizer photobleaching coefficient and O-1(2) quantum yield, which have been measured in several previous studies. Results of the simulation using clinical magnetic resonance imaging data show the need to specify the insertion positions of cylindrical light diffusers and the level of light fluence. Detailed analysis with a numerical brain tumor model demonstrates that ALA-iPDT treatment outcomes depend on combinations of photobleaching and threshold values. These results indicate that individual medical procedures, including pretreatment planning and treatment monitoring, will greatly benefit from simulation of ALA-iPDT outcomes. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.