Gene expression studies in leiomyomata: new directions for research.
Gene expression studies in leiomyomata: new directions for research.
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平滑肌瘤的基因表达研究：研究的新方向。
DOI：
10.1055/s-2004-828614
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发表时间：
2004
影响因子：
2.7
通讯作者：
Segars,James
中科院分区：
文献类型：
--
作者：
Catherino,William;Salama,Amal;Potlog-Nahari,Clariss;Leppert,Phyllis;Tsibris,John;Segars,James
子宫平滑肌瘤（肌瘤）是女性的一个主要健康问题，导致严重的发病率和手术干预。作为良性克隆肿瘤，平滑肌瘤也代表了非常适合分子分析的靶点。家族研究和以平滑肌瘤为特征的遗传综合征提供了令人信服的证据，表明基因改变可能导致肌瘤的发展，但参与平滑肌瘤发展的特定基因尚未确定。微阵列可以同时比较数千个基因的相对表达，从而突出显示可能在平滑肌瘤发育中发挥作用的特定基因。几个实验室进行的微阵列研究已经确定了候选基因。然而，很少有基因产物已通过替代实验方法得到证实。本文的目的是重点关注调查平滑肌瘤发展的微阵列研究提供的见解。这些研究表明，尽管观察到了子宫肌瘤生长的激素控制，但还有其他涉及子宫肌瘤细胞表型发育的关键途径值得研究。特别是，平滑肌瘤中细胞外基质基因的表达紊乱，此类基因代表了潜在的新治疗靶点。
Uterine leiomyomata (fibroids) are a leading women’s health problem, resulting in significant morbidity and surgical intervention. As benign clonal tumors, leiomyomata also represent a target well suited to molecular analysis. Familial studies and genetic syndromes featuring leiomyomata provide compelling evidence that genetic alterations may cause fibroid development, but the specific genes involved in leiomyoma development have not been identified. Microarrays permit simultaneous comparison of the relative expression of thousands of genes, thereby highlighting specific genes that may play a role in the development of leiomyomata. Microarray studies conducted by several laboratories have identified candidate genes. However, few gene products have been confirmed with alternative experimental approaches. The objective of this article is to focus on the insights provided by microarray studies investigating leiomyoma development. Such studies suggest that although hormonal control of leiomyoma growth is observed, there are other critical pathways involved in development of the leiomyoma cell phenotype that warrant investigation. In particular, expression of extracellular matrix genes in leiomyomata is deranged and such genes represent potential novel targets for therapy.