Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer
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DOI：
10.1016/j.bmcl.2019.05.022
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发表时间：
2019-07-15
影响因子：
2.7
通讯作者：
Sakurai, Kaori
中科院分区：
文献类型：
--
作者：
Kimura, Mayu;Sasaki, Kanae;Sakurai, Kaori
OSW-1是一种植物来源的天然产物，通过与氧固醇结合蛋白家族的成员结合，从而破坏脂质/固醇体内平衡，从而选择性地杀死癌细胞。然而，这些蛋白质-配体相互作用如何介导细胞死亡信号仍然难以捉摸。在这里，我们发现OSW-1选择性地激活高尔基体应激反应，导致细胞凋亡，为OSW-1的抗癌活性提供了机制基础。
OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to apoptosis, providing a mechanistic basis for the anticancer activity of OSW-1.