ADIPOQ +45T>G, +712A>G and +4545C>G variants are associated with dyslipidemia in Chinese pre-eclampsia women
ADIPOQ +45T>G, +712A>G and +4545C>G variants are associated with dyslipidemia in Chinese pre-eclampsia women
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DOI：
10.1007/s13410-014-0251-6
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发表时间：
2015-09
影响因子：
0.9
通讯作者：
Xian-hua Yu;Z. Yin;Hui Lin;N. Lin;Yuan Lin;Juan Chen;Suijin Lin;Yanping Lin;Yuanzhong Chen;K. Lu;Hekun Liu
中科院分区：
文献类型：
--
作者：
Xian-hua Yu;Z. Yin;Hui Lin;N. Lin;Yuan Lin;Juan Chen;Suijin Lin;Yanping Lin;Yuanzhong Chen;K. Lu;Hekun Liu
先兆子痫是产科最常见的并发症，其发病机制尚不清楚。以家庭为基础的研究表明，先兆子痫的发生率与遗传因素有关。血脂谱显示子痫前期还伴有血脂异常。本研究旨在探讨脂肪最丰富基因转录本-1、脂联素(ADIPOQ)基因常见的多态性对中国汉族妊娠妇女脂代谢及子痫前期的影响。纳入临床明确的子痫前期患者( )221例和健康孕妇( )271例。采用聚合酶链式反应-限制性片段长度多态性方法检测ADIPOQ+45T/G、+712A/G和+4545C/G单核苷酸多态。根据SNPs和组别分析代谢和临床数据的变化。病例组+45TT基因携带者的载脂蛋白A1水平明显低于G等位基因携带者(p= 0.002)。在对照组中，+712AA等位基因携带者的收缩压高于G等位基因携带者(p= 0.009)，+4545CC携带者高于G等位基因携带者(p= 0.009)。尚未观察到ADIPOQ基因或等位基因与先兆子痫的显著关联。+45T>；G与+712A>；G、+45T>；G与+4545T>；G、+712A>；G与+45T>；G之间存在较强的连锁不平衡。ADIPOQ基因的3个多态位点不是中国女性子痫前期易感性的主要遗传决定因素，但ADIPOQ基因可能影响子痫前期患者的SBP和脂质代谢。
The pathogenesis of pre-eclampsia, the most common complication in obstetrics, is unclear. Family based studies have shown that the incidence of pre-eclampsia is related to genetic factors. Lipid profile indicated that pre-eclampsia were also accompanied by dyslipidemia. We would like to evaluate the influence of common polymorphisms of the adipose most abundant gene transcript-1, adiponectin (ADIPOQ) gene on the lipid metabolism, and pre-eclampsia in Chinese Han women of pregnancy. Clinically defined pre-eclampsia patients (n= 221) and healthy pregnant women (n= 271) were recruited. PCR-RFLP was used to genotypeADIPOQ+45T/G, +712A/G, and +4545C/G single-nucleotide polymorphisms (SNPs). Changes in metabolic and clinical data were analyzed according to SNPs and groups. +45TT genotype had a relatively lower ApoA1 level than G-allele carrier in case group (p= 0.002). In the controls, systolic blood pressure (SBP) levels were higher in +712AA genotype group than G-allele carriers’ (p= 0.009), +4545CC were higher than G-allele carriers’ (p= 0.009). No significant association between theADIPOQgenotype or the alleles and pre-eclampsia had been observed. There is a strong linkage disequilibrium between polymorphic loci +45T>G and +712A>G, +45T>G and +4545T>G, and +712A>G and +4545T>G, respectively. ADIPOQ gene might affect SBP and lipid metabolism of pre-eclampsia, although the three polymorphic sites onADIPOQgene are not the major genetic determinants of susceptibility to pre-eclampsia in Chinese women.