Emerging themes in non-coding RNA quality control.
Emerging themes in non-coding RNA quality control.
复制标题
非编码 RNA 质量控制的新兴主题。
DOI：
10.1016/j.sbi.2007.03.012
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发表时间：
2007
影响因子：
6.8
通讯作者：
Wolin,SandraL
中科院分区：
文献类型：
--
作者：
Reinisch,KarinM;Wolin,SandraL
非编码 RNA（例如 tRNA 和 rRNA）的质量控制途径很普遍。在原核生物和真核生物中，poly(A) 聚合酶都会靶向异常的非编码 RNA 进行降解。在酵母中，包含多聚腺苷酸聚合酶 Trf4p 的核复合物与外泌体一起降解多种非编码 RNA，其中一些是异常的。酵母还有其他降解缺陷 RNA 的途径，其他途径可能存在于高等真核生物中。一种可能性是，细胞识别出错误折叠 RNA 所共有的特定的、尚未被发现的特征。然而，另一种选择是RNA质量控制蛋白与相对通用的RNA结构相互作用，而正确折叠的RNA则被特定的RNA结合蛋白隔离，从而防止降解。最近获得的参与非编码 RNA 质量控制的蛋白质和核糖核蛋白复合物的结构使人们对这一过程有了更详细的了解。
Quality control pathways for non-coding RNAs such as tRNAs and rRNAs are widespread. In both prokaryotes and eukaryotes, poly(A) polymerases target aberrant non-coding RNAs for degradation. In yeast, a nuclear complex that includes the poly(A) polymerase Trf4p works together with the exosome in degrading a broad array of non-coding RNAs, several of which are aberrant. Yeast also have additional pathways for the degradation of defective RNAs and other pathways may exist in higher eukaryotes. One possibility is that cells recognize specific, still undiscovered, features common to misfolded RNAs; however, an alternative is that RNA quality control proteins interact with relatively general RNA structures, whereas correctly folded RNAs are sequestered by specific RNA-binding proteins and thus protected from degradation. Recently available structures of protein and ribonucleoprotein complexes involved in non-coding RNA quality control are providing a more detailed understanding of this process.