A novel natural mutation in HC-Pro responsible for mild symptomatology of Zucchini yellow mosaic virus (ZYMV, Potyvirus) in cucurbits
A novel natural mutation in HC-Pro responsible for mild symptomatology of Zucchini yellow mosaic virus (ZYMV, Potyvirus) in cucurbits
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DOI：
10.1007/s00705-009-0569-4
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Lecoq, H.
中科院分区：
文献类型：
--
作者：
Desbiez, Cecile;Girard, M.;Lecoq, H.
A natural mild isolate of Zucchini yellow mosaic virus was found to contain a mutation in the helper component (HC-Pro) within a conserved motif, "CDNQLD", located 12 residues downstream from the "FRNK" motif involved in symptom severity. Introducing the mutation in an infectious cDNA clone of ZYMV resulted in an almost complete absence of symptoms, although viral accumulation was only partially reduced. The FRNK(X)(12)CDNQLD sequence might be part of a larger motif that is conserved in potyviruses and plays a role in symptomatology and/or silencing inhibition.
