Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum
Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum
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DOI：
10.1016/s0304-3940(02)01123-0
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发表时间：
2002-12-13
影响因子：
2.5
通讯作者：
Miller, R
中科院分区：
文献类型：
--
作者：
Heaton, MB;Paiva, M;Miller, R
新生儿小脑经历了一个早期的乙醇敏感性，其中深刻的神经元损失被视为急性暴露后，而稍晚的曝光产生没有这样的损失。本研究旨在确定这种差异敏感性是否与乙醇诱导的活性氧（ROS）产生的差异有关。我们发现，在出生后第4天（P4），小脑脆弱性的高峰期，乙醇治疗，导致ROS增加，但稍晚曝光（P7）产生的ROS没有立即的变化，但减少被视为在12和24小时后曝光。在P14上的暴露产生ROS产生的一致降低。因此，在氧化过程中的差异反应可能发挥了重要作用，在不同的时间乙醇脆弱性的发展小脑。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The neonatal cerebellum undergoes an early period of ethanol sensitivity in which profound neuronal loss is seen following acute exposure, while slightly later exposure produces no such loss. This study was designed to determine whether this differential susceptibility is related to differences in ethanol-induced generation of reactive oxygen species (ROS). We found that ethanol treatment on postnatal day 4 (P4), the peak period of cerebellar vulnerability, resulted in ROS increases, but slightly later exposure (on P7) produced no immediate changes in ROS, but reductions were seen at 12 and 24 h following exposure. Exposure on P14 produced consistent decreases in ROS production. Thus, differential responsiveness in oxidative processes may play a major role in the differential temporal ethanol vulnerability of developing cerebellum. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.