Beneficial effects of designed dietary fatty acid compositions on lipids in triacylglycerol-rich lipoproteins among Chinese patients with type 2 diabetes mellitus"
Beneficial effects of designed dietary fatty acid compositions on lipids in triacylglycerol-rich lipoproteins among Chinese patients with type 2 diabetes mellitus"
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DOI：
10.1016/j.metabol.2008.11.010
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发表时间：
2009-04-01
影响因子：
9.8
通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
--
作者：
Dai, Jun;Su, Yi-Xiang;Vaccarino, Viola
餐后富含三酰基甘油的脂蛋白（ppTRL）水平升高会导致动脉粥样硬化。 2 型糖尿病 (T2DM) 患者餐后脂血症严重，与 ppTRL 残余物升高或停留时间延长有关。我们研究了膳食脂肪酸成分 (DFAC) 是否能降低中国 T2DM 患者 ppTRL 亚组分中致动脉粥样硬化的脂质谱。在 28 名 T2DM 患者中进行了一项单盲随机对照试验。患者食用 3 种标准化 DFAC 特定脂肪餐中的 1 种：等量 (1:1:1)、多不饱和脂肪酸 (PUFA) 为主 (PUFA-D，1:1.7:2.3) 或单不饱和脂肪酸 (MUFA) 为主 (MUFA-D，1:1.7:1.2)。括号内的数字分别表示饱和脂肪酸、MUFA、PUFA与饱和脂肪酸的比例。 MUFA-D 膳食作为对照。在禁食（0小时）和食用脂肪餐后2、4和6小时时，以大于400、S(f) 60至400、S(f) 20至60和S(f) 12至20 ppTRL亚分数测量三酰甘油和胆固醇水平。使用线性混合模型评估 DFAC 对 ppTRL 亚组分中 0、2、4 和 6 小时内平均三酰甘油和胆固醇平均浓度的影响。使用 400 个（P = .002，bootstrap P < .05）和 S(f) 20 至 60（P = .02，bootstrap p < .05）亚分数验证了稳定性和稳健性，并降低了平均 S(f) 20 至 60 胆固醇（P = .04 bootstrap P < .05）； PUFA-D 使 S(f) 降低超过 400 平均三酰甘油水平（P = .09，bootstrap P < .05）。 Bootstrap 样本表明 PUFA-D 降低了平均 S(f) 20 至 60 胆固醇水平（bootstrap P < .05）。因此，修改 DFAC 可减轻 ppTRL 在 T2DM 患者中的致动脉粥样硬化脂质谱。但增加 PUFA 比例可能更可行 (C) 2009 Elsevier Inc. 保留所有权利。
Elevated levels of postprandial tiracylglycerol-rich lipoproteins (ppTRLs) are atherogenic. Patients with type 2 diabetes mellitus (T2DM) have exaggerated postprandial lipemia associated with elevation or prolonged residence of ppTRL remnants. We examined whether dietary fatty acid compositions (DFACs) decrease atherogenic lipid profiles in ppTRL subfractions in T2DM Chinese patients. A singe-blind randomized controlled trial was conducted among 28 T2DM patients. Patients consumed 1 of 3 standardized DFAC-specific fat meals: equidominant (1:1:1), polyunsaturated fatty acid (PUFA) dominant (PUFA-D, 1:1.7:2.3), or monounstaturated fatty acid (MUFA)-dominant (MUFA-D, 1:1.7:1.2) meals. Numbers in parenthesis, respectively, represent the ratio of saturated fatty acids, MUFA, and PUFA to saturated fatty acids. The MUFA-D meal was the control. Triacylglycerol and cholesterol levels were measured in Svedberg floatation rate (S(f)) greater than 400, S(f) 60 to 400, S(f) 20 to 60, and S(f) 12 to 20 ppTRL subfractions at fasting (0 hour) and 2, 4 and 6 hours after the consumption of the fat meals. Effects of DFACs on mean concentrations of triacylglycerols and cholesterol averaged over 0, 2, 4 and 6 hours in ppTRL subfraction were assessed using linear mixed models. Stability and robustness were validated with 400 (P = .002, bootstrap P < .05) and S(f) 20 to 60 (P = .02, bootstrap p < .05) subfractions, and decreased average S(f) 20 to 60 cholesterol (P = .04 bootstrap P < .05); PUFA-D decreased S(f) greater than 400 average triacylglycerol levels (P = .09, bootstrap P < .05). Bootstrap samples suggested that PUFA-D decreased average S(f) 20 to 60 cholesterol levels (bootstrap P < .05). Therefore, modifying DFACs attenuates the atherogenic lipid profile of ppTRLs in T2DM patients; but increasing PUFA ratio may be more feasible (C) 2009 Elsevier Inc. All rights reserved.