Zero-lag synchronous dynamics in triplets of interconnected cortical areas
Zero-lag synchronous dynamics in triplets of interconnected cortical areas
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DOI：
10.1016/s0893-6080(01)00043-0
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发表时间：
2001-07-01
期刊：
影响因子：
7.8
通讯作者：
Lumer, ED
中科院分区：
文献类型：
--
作者：
Chawla, D;Friston, KJ;Lumer, ED
涉及新皮质中广泛神经元群体的振荡和同步活动与复杂感觉运动任务的执行相关，并且已被提议参与知觉合成过程中感觉属性的“结合”。大脑如何构建这些连贯的放电模式仍然很大程度上未知。已经考虑了几种皮质内同步机制，特别是相互抑制和相互兴奋。这些机制无法解释位于视觉层次结构中不同级别的区域之间观察到的零滞后相关性，因为该层次结构中上升和下降连接的不对称层状组织将预测系统的区域间相位滞后。在这里，我们通过详细的计算机模拟表明，当考虑皮质层次结构中的三元组而不是成对的相互连接区域时，零滞后同步会自然地从它们的三向交互中出现。这些模拟的动机是观察到猫和猕猴视觉皮层的大部分区域都组织成这样的三联体。我们的结果表明，哺乳动物新皮质的解剖连接模式为神经元活动的多级同步提供了结构基础。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Oscillatory and synchronized activities involving widespread populations of neurons in neocortex are associated with the execution of complex sensorimotor tasks and have been proposed to participate in the 'binding' of sensory attributes during perceptual synthesis. How the brain constructs these coherent firing patterns remains largely unknown. Several mechanisms of intracortical synchronization have been considered, in particular mutual inhibition and reciprocal excitation. These mechanisms fail to account for the zero-lag correlations observed among areas located at different levels in the visual hierarchy because the asymmetric laminar organization of ascending and descending connections in this hierarchy would predict systematic inter-areal phase lags. Here we show through detailed computer simulations that, when triplets rather than pairs of reciprocally connected areas in a cortical hierarchy are considered, zero-lag synchronization emerges naturally from their three-way interactions. These simulations were motivated by the observation that most areas in the cat and macaque monkey visual cortex are organized in such triplets. Our results suggest that patterns of anatomical connections in the mammalian neocortex provide a structural basis for the multi-level synchronization of neuronal activity. (C) 2001 Elsevier Science Ltd. All rights reserved.