Porfimer sodium photodynamic therapy for management of Barrett's esophagus with high-grade dysplasia
Porfimer sodium photodynamic therapy for management of Barrett's esophagus with high-grade dysplasia
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DOI：
10.1002/lsm.20367
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发表时间：
2006-06-01
影响因子：
2.4
通讯作者：
Overholt, Bergein F.
中科院分区：
文献类型：
--
作者：
Panjehpour, Masoud;Overholt, Bergein F.
用于Barrett食管的Porfimer钠光动力疗法（ps-PDT）是一种强大的内窥镜治疗，可以消除高度异型增生（HGD）和Barrett粘膜，并降低这些患者发生癌症的风险。Ps-PDT通常导致治疗区域大部分的巴雷特食管破坏。然而，PDT后残留的小Barrett粘膜岛可能持续存在。因此，在随访内窥镜检查过程中，辅助热消融应可用于消融Barrett粘膜的残留岛。PDT应与有效的质子泵抑制剂治疗同时应用。本文为应用泊菲默钠球囊PDT治疗Barrett食管伴HGD提供了实用指南。建议提供患者的选择和筛选，光动力治疗，包括光剂量测定，方法后续内窥镜检查，以及讨论潜在的副作用和并发症。
Porfimer sodium photodynamic therapy (ps-PDT) for Barrett's esophagus is a powerful endoscopic treatment that can eliminate high-grade dysplasia (HGD) and Barrett's mucosa and reduce the risk of development of cancer in these patients. Ps-PDT typically results in destruction of Barrett's esophagus in the majority of the treated area. However, residual small island of Barrett's mucosa may persist after PDT. Therefore, adjuvant thermal ablation should be available during follow-up endoscopies for ablation of residual islands of Barrett's mucosa. PDT should be applied concurrent with effective proton pump inhibitor therapy. This article provides a practical guide for application of porfimer sodium balloon PDT for management of Barrett's esophagus with HGD. Recommendations are provided for patient selection and screening, delivery of PDT to include light dosimetry, methodology for follow-up endoscopies, as well as discussing the potential side effects and complications.