The Significance and Limited Influence of Cerebrovascular Reactivity on Age and Sex Effects in Task- and Resting-State Brain Activity.
The Significance and Limited Influence of Cerebrovascular Reactivity on Age and Sex Effects in Task- and Resting-State Brain Activity.
复制标题
脑血管反应性对任务和静息状态大脑活动中年龄和性别影响的意义和有限影响。
DOI：
10.1101/2023.08.18.553848
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Biswal,BharatB
中科院分区：
文献类型：
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作者：
Chen,DonnaY;Di,Xin;Yu,Xin;Biswal,BharatB
功能性MRI测量血氧水平依赖性信号，其提供了由神经血管反应介导的神经活动的间接测量。脑血管反应性影响任务诱导和静息状态血氧水平依赖性活动，并可能混淆个体间效应，如与衰老和生物性别相关的效应。我们研究了一个包含屏气，棋盘和休息状态任务的大型数据集。我们使用屏气任务来测量脑血管反应性，使用棋盘任务来获得基于任务的激活，并量化静息态活动的低频波动幅度和区域均匀性。我们假设脑血管反应性与血氧水平依赖性指标相关，考虑到这些相关性，可以更好地估计年龄和性别的影响。我们发现，脑血管反应性与棋盘任务激活的视觉皮层和低频波动的幅度和区域均匀性，在广泛的额顶叶区域，以及大血管的地区。我们还发现了脑血管反应性的显着年龄和性别效应，其中一些重叠的低频波动和区域均匀性的振幅观察。然而，校正脑血管反应性的影响对年龄和性别的估计影响非常有限。我们的研究结果强调了目前屏气任务对脑血管反应性的限制。
Functional MRI measures the blood-oxygen-level dependent signals, which provide an indirect measure of neural activity mediated by neurovascular responses. Cerebrovascular reactivity affects both task-induced and resting-state blood-oxygen-level dependent activity and may confound inter-individual effects, such as those related to aging and biological sex. We examined a large dataset containing breath-holding, checkerboard, and resting-state tasks. We used the breath-holding task to measure cerebrovascular reactivity, used the checkerboard task to obtain task-based activations, and quantified resting-state activity with amplitude of low-frequency fluctuations and regional homogeneity. We hypothesized that cerebrovascular reactivity would be correlated with blood-oxygen-level dependent measures and that accounting for these correlations would result in better estimates of age and sex effects. We found that cerebrovascular reactivity was correlated with checkerboard task activations in the visual cortex and with amplitude of low-frequency fluctuations and regional homogeneity in widespread fronto-parietal regions, as well as regions with large vessels. We also found significant age and sex effects in cerebrovascular reactivity, some of which overlapped with those observed in amplitude of low-frequency fluctuations and regional homogeneity. However, correcting for the effects of cerebrovascular reactivity had very limited influence on the estimates of age and sex. Our results highlight the limitations of accounting for cerebrovascular reactivity with the current breath-holding task.