Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
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皮肤血管同时受到感觉纤维、交感纤维和副交感纤维的支配
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
A. Ribeiro
中科院分区：
文献类型：
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作者：
I. Ruocco;A. Cuello;A. Parent;A. Ribeiro
尽管已知皮肤血管神经支配在血流控制中的主要作用，特别是在疾病中，但关于感觉和自主神经纤维对血管的共同神经支配以及这些纤维彼此之间的关系的信息很少。为了填补这一空白，我们进行了光和电子显微镜分析皮肤血管的感觉和自主神经纤维的神经支配，以大鼠和猴下唇为模型。在大鼠中，双标记免疫细胞化学显示，P物质（SP）和多巴胺β羟化酶（DβH）、SP和囊泡乙酰胆碱转运体（VAChT）以及DβH和VAChT免疫反应性纤维的组合仅出现在真皮下部的血管周围。所有类型的纤维平行移动，彼此非常接近。在真皮上层，血管仅由含SP纤维支配。虽然神经末梢显示突触囊泡，但从未观察到突触特化，这表明，在这一领域，这些纤维不建立突触接触。定量的各种免疫反应终端和他们的假定目标（平滑肌细胞和内皮细胞）之间的距离显示，交感神经和副交感神经纤维显着更接近内皮细胞层和平滑肌细胞相比，感觉纤维。在猴中，仅对SP‐DβH和SP‐VAChT进行双标记免疫细胞化学。获得的结果与在大鼠中发现的结果相似;然而，猴子中的纤维密度更大。提示皮肤微循环的调节可能是感觉纤维和自主神经纤维协调作用的结果。神经学比较杂志448：323-336，2002.© 2002 Wiley利斯公司
Despite the known major role of skin blood vessel innervation in blood flow control, particularly in disease, little information on the co‐innervation of blood vessels by sensory and autonomic fibers and the relationships of these fibers to one another is available. To fill this gap, we performed a light and electron microscopic analysis of the innervation of skin vessels by sensory and autonomic fibers by using the rat and monkey lower lips as a model. In rats, double‐labeling immunocytochemistry revealed that combinations of fibers immunoreactive for substance P (SP) and dopamine‐β‐hydroxylase (DβH), SP and vesicular acetylcholine transporter (VAChT), as well as DβH and VAChT occurred only around blood vessels in the lower dermis. All fiber types travelled in parallel and in close proximity to one another. In the upper dermis, blood vessels were innervated by SP‐containing fibers only. Although nerve terminals displayed synaptic vesicles, synaptic specializations were never observed, suggesting that, in this territory, these fibers do not establish synaptic contacts. Quantification of the distance between the various immunoreactive terminals and their presumptive targets (smooth muscle cells and endothelial cells) revealed that both sympathetic and parasympathetic fibers were significantly closer to the endothelial cell layer and smooth muscle cells compared with sensory fibers. In monkeys, double‐labeling immunocytochemistry was performed for SP‐DβH and SP‐VAChT only. The results obtained are similar to those found in rats; however, the fiber density was greater in monkeys. Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers. J. Comp. Neurol. 448:323–336, 2002. © 2002 Wiley‐Liss, Inc.
影响因子：
20.1
作者：
Tianen Yang;M. N. Levy
通讯作者：
Tianen Yang;M. N. Levy