On the Origin of Superoxide Dismutase: An Evolutionary Perspective of Superoxide-Mediated Redox Signaling.
On the Origin of Superoxide Dismutase: An Evolutionary Perspective of Superoxide-Mediated Redox Signaling.
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DOI：
10.3390/antiox6040082
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发表时间：
2017-10-30
期刊：
影响因子：
--
通讯作者：
Case AJ
中科院分区：
文献类型：
--
作者：
Case AJ
自由基生物学领域起源于1969年超氧化物歧化酶（SOD）的发现。在过去的50年里，从细菌到哺乳动物，已经进行了大量的研究，阐明了SOD的分子反应，亚细胞位置和特异性同工型。然而，虽然人类在过去50年才开始研究这类酶，但据估计，这些酶已经存在了数十亿年，并且可能是原始生命中发现的一些原始酶。随着生命在这段时间内的进化，这些酶已经承担了新的和不同的功能角色，与它们最初的来源形成了鲜明的对比。在此，这些酶的进化历史的检查提供了一个解释和进一步调查到现代的SOD在生理和疾病中的作用。
The field of free radical biology originated with the discovery of superoxide dismutase (SOD) in 1969. Over the last 5 decades, a plethora of research has been performed in species ranging from bacteria to mammals that has elucidated the molecular reaction, subcellular location, and specific isoforms of SOD. However, while humans have only begun to study this class of enzymes over the past 50 years, it has been estimated that these enzymes have existed for billions of years, and may be some of the original enzymes found in primitive life. As life evolved over this expanse of time, these enzymes have taken on new and different functional roles potentially in contrast to how they were originally derived. Herein, examination of the evolutionary history of these enzymes provides both an explanation and further inquiries into the modern-day role of SOD in physiology and disease.
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