The development of bladder tumors and contralateral upper urinary tract tumors after primary transitional cell carcinoma of the upper urinary tract
The development of bladder tumors and contralateral upper urinary tract tumors after primary transitional cell carcinoma of the upper urinary tract
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DOI：
10.1002/cncr.11691
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发表时间：
2003-10-15
期刊：
影响因子：
6.2
通讯作者：
Shiue, YL
中科院分区：
文献类型：
--
作者：
Kang, CH;Yu, TJ;Shiue, YL
背景。原发性移行细胞癌 (TCC) 后的对侧异时上尿路 (UUT) 肿瘤的报道很少，据作者所知，迄今为止尚未确定危险因素。此外，很少有报道描述复发性膀胱肿瘤和对侧UUT肿瘤的特征以及这些肿瘤类型之间的关系。方法。对 223 名有记录的原发性 UUT-TCC 患者的数据进行了统计分析。排除双侧受累和远处转移后，对189名患者的12个变量进行多变量分析，以确定复发性尿路上皮肿瘤的危险因素。 结果。膀胱肿瘤复发率31.2%，对侧UUT肿瘤复发率5.8%。多重性被确定为膀胱肿瘤复发的危险因素。肾功能不全、尿毒症和并发膀胱肿瘤显着使患者容易出现对侧。原发性 UUT-TCC 后的 UUT 肿瘤。复发性膀胱肿瘤和对侧 UUT 肿瘤之间的时间间隔和分期分布存在显着差异。与患有对侧异时性 UUT 肿瘤的患者相比，患有复发性膀胱肿瘤的患者肿瘤处于早期阶段，并且复发时间更短。结论。对于原发性 UUT-TCC 患者，需要定期进行膀胱镜检查以发现复发性膀胱肿瘤。对于对侧 UUT 肿瘤风险较高的患者，应进行静脉尿路造影或逆行肾盂造影。 (C) 2003 年美国癌症协会。
BACKGROUND. Contralateral, metachronous upper urinary tract (UUT) tumors after primary transitional cell carcinoma (TCC) of the UUT are reported rarely, and to the authors' knowledge the risk factors have not been determined to date. In addition, few reports have described the characteristics of recurrent bladder tumors and contralateral UUT tumors and any relation between theses tumor types.METHODS. Statistical analysis of data from 223 patients with documented primary UUT-TCC was undertaken. After excluding bilateral involvement and distant metastases, 12 variables were analyzed by multivariate analysis in 189 patients to determine the risk factors for recurrent urothelial tumors.RESULTS. The incidence rates of recurrent bladder tumors and contralateral UUT tumors were 31.2% and 5.8%, respectively. Multiplicity was determined as a risk factor for recurrent bladder tumors. Renal insufficiency, uremia, and concurrent bladder tumors significantly predisposed patients to develop contralateral. UUT tumors after primary UUT-TCC. The time intervals and stage distributions differed significantly between recurrent bladder tumors and contralateral UUT tumors. Patients who had recurrent bladder tumors had earlier stage tumors and had a shorter time to recur compared with patients who had contralateral, metachronous UUT tumors.CONCLUSIONS. For patients with primary UUT-TCC, regular follow-up by cystoscopy is necessary to detect recurrent bladder tumors. Intravenous urography or retrograde pyelography should be performed for patients who have a high risk of developing contralateral UUT tumors. (C) 2003 American Cancer Society.