Epstein-Barr virus and cytomegalovirus in autoimmune diseases - Are they truly notorious? A preliminary report
Epstein-Barr virus and cytomegalovirus in autoimmune diseases - Are they truly notorious? A preliminary report
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DOI：
10.1196/annals.1422.059
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Shoenfeld, Y.
中科院分区：
文献类型：
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作者：
Barzilai, O.;Sherer, Y.;Shoenfeld, Y.
迄今为止，人们认为自身免疫性疾病的起源是一个多因素的背景。遗传易感性、免疫系统功能障碍甚至事与愿违、激素调节和环境因素都在自身免疫性疾病的发病机制中发挥重要作用。在这些环境因素中，感染的作用是已知的一个主要因素。eb病毒（EBV）和巨细胞病毒（CMV）被认为是臭名昭著的，因为它们一直与多种自身免疫性疾病有关。对23种不同自身免疫性疾病组的1595份血清样本进行了筛查，以寻找既往感染EBV和CMV的证据。使用Bio-Rad的BioPlex 2200对所有样本进行EBV核抗原-1 （IgG）、EBV病毒衣壳抗原（IgG和IgM）、EBV早期抗原（IgG）、EBV嗜异性抗体和CMV （IgG和IgM）抗体的筛选。结果显示，与健康对照相比，各种EBV靶物的滴度显著增加，因此提出了EBV与多发性肌炎之间的新联系。我们的研究结果也支持了先前关于EBV与多种自身免疫性疾病（包括SLE、抗磷脂综合征、类风湿性关节炎、多发性硬化症、寻常性天疱疮、巨细胞关节炎、韦格纳肉芽肿病和结节性多动脉炎）之间存在关联的信息。SLE患者血清CMV IgG抗体水平升高。我们的数据支持EBV与许多自身免疫性疾病有关的理论。巨细胞病毒似乎也与自身免疫性疾病有关，但建立这一理论需要进一步的研究。
To date, it is believed that the origin of autoimmune diseases is one of a multifactorial background. A genetic predisposition, an immune system malfunction or even backfire, hormonal regulation, and environmental factors all play important roles in the pathogenesis of autoimmune diseases. Among these environmental factors, the role of infection is known to be a major one. Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are considered to be notorious as they are consistently associated with multiple autoimmune diseases. A cohort of 1595 serum samples, of 23 different autoimmune disease groups, was screened for evidence of prior infection with EBV and CMV. All samples were screened for antibodies against EBV nuclear antigen-1 (IgG), EBV viral capsid antigen (IgG and IgM), EBV early antigen (IgG), EBV heterophile antibody, and CMV (IgG and IgM) antibodies using Bio-Rad's BioPlex 2200. A new association is proposed between EBV and polymyositis, as results show a significant increase in titers of various EBV target analytes when compared with healthy controls. Our results also support prior information suggesting the association between EBV and multiple autoimmune diseases, including SLE, antiphospholipid syndrome, rheumatoid arthritis, multiple sclerosis, pemphigus vulgaris, giant cell arthritis, Wegener's granulomatosis, and polyarteritis nodosa (PAN). Elevated CMV IgG titers were observed in sera of SLE patients. Our data support the theory that EBV is notoriously associated with many autoimmune diseases. CMV appears to be associated to autoimmune diseases as well, yet establishing this theory requires further investigation.