Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis
Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis
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DOI：
10.1111/j.1365-2796.2005.01543.x
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发表时间：
2005-09-01
影响因子：
11.1
通讯作者：
Tilg, H
中科院分区：
文献类型：
--
作者：
Kaser, S;Moschen, A;Tilg, H
背景资料。脂肪细胞因子脂联素被认为在调节能量稳态、胰岛素敏感性等方面发挥重要作用，并具有抗炎作用。在本研究中，我们研究了循环脂联素在不同慢性肝病中的作用、全身抗肿瘤坏死因子-α治疗对其的调节以及其肝脏代谢。检测87例不同病因的肝硬变患者、7例酒精性脂肪性肝炎患者、11例经颈静脉肝内门体分流术治疗的肝硬变患者和21例健康对照组的血浆脂联素水平。与健康对照组相比，所有不同病因的肝硬变患者的脂联素水平均显著升高，且随Child-Pugh分级的增加而增加。在酒精性脂肪性肝炎患者中，全身性抗肿瘤坏死因子-α治疗导致循环脂联素显著下降。门静脉、肝静脉和外周静脉的脂联素浓度相似。在任何一组患者中，脂联素水平与胰岛素抵抗均无相关性。我们的数据表明，循环脂联素在肝硬变患者中升高，与肝病的病因无关。我们认为慢性肝病中高水平的脂联素可能反映了慢性肝病中机体的抗炎机制之一。
Background. The adipocytokine adiponectin has been proposed to play important roles in the regulation of energy homeostasis, insulin sensitivity and shows anti-inflammatory properties.Aim. In this study we investigated the role of circulating adiponectin in different chronic liver diseases, its regulation by systemic anti-tumour necrosis factor (TNF)-alpha treatment and its hepatic metabolism.Patients and methods. Plasma adiponectin levels were determined in 87 patients with liver cirrhosis of different aetiologies, seven patients with alcoholic steatohepatitis undergoing systemic anti-TNF-alpha treatment, in 11 patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt implantation and in 21 healthy controls.Results. Adiponectin levels were significantly higher in all subjects with liver cirrhosis of different aetiologies when compared with healthy controls and increased dependent on Child-Pugh classification. In subjects with alcoholic steatohepatitis, systemic anti-TNF-alpha treatment caused a significant decrease in circulating adiponectin. Adiponectin concentrations were similar in portal, hepatic and peripheral veins. No correlation between adiponectin levels and insulin resistance was found in any patient group.Conclusions. Our data suggest that circulating adiponectin is increased in liver cirrhosis independent of the aetiology of liver disease. We suggest that high adiponectin levels in chronic liver disease might reflect one of the body's anti-inflammatory mechanisms in chronic liver diseases.