Prenatal nicotine exposure alters neuroanatomical organization of the developing brain
Prenatal nicotine exposure alters neuroanatomical organization of the developing brain
复制标题
DOI：
10.1002/syn.21589
复制
发表时间：
2012-11-01
期刊：
影响因子：
2.3
通讯作者：
Kolb, Bryan
中科院分区：
文献类型：
--
作者：
Muhammad, Arif;Mychasiuk, Richelle;Kolb, Bryan
尽管已经有相当多的关于产前接触尼古丁的长期影响的研究，但很少有关于这种经历如何影响大脑发育的研究。本研究旨在检查妊娠期暴露于尼古丁是否存在内侧前额叶皮质、眶额叶皮质、顶叶皮质和伏隔核的形态学变化（树突分支、树突长度和脊柱密度）。在怀孕期间，给怀孕的朗埃文斯鼠服用尼古丁或生理盐水。使用高尔基-考克斯技术检查出生后21天子代的神经解剖学。在产前暴露于尼古丁的大鼠中发现的树突变化与成年后服用尼古丁的大鼠发现的神经解剖学变化相似。在测量的18个解剖参数中，有11个表现出明显的改变，其中顶叶皮质的根尖和基底棘密度两个参数表现出性别依赖性的改变。这些解剖学和行为的早期变化对后来的可塑性和长期健康有着重要的影响。中文信息学报，2012。(C) 2012 Wiley期刊公司
Although there has been considerable research conducted regarding the long-term effects of prenatal exposure to nicotine, there has been little examination of how this experience influences brain development. This study was designed to examine if there are morphological changes (dendritic branching, dendritic length, and spine density) in medial prefrontal cortex, orbital frontal cortex, parietal cortex, and nucleus accumbens associated with exposure to nicotine during gestation. Nicotine or saline was administered to pregnant Long Evans dams for the duration of pregnancy. Golgi-Cox techniques were used to examine neuroanatomy of offspring at postnatal day 21. The dendritic changes identified in rats exposed to nicotine prenatally resembled neuroanatomical changes that are identified in rats administered with nicotine in adulthood. Of the 18 anatomical parameters measured, 11 exhibited significant modification, with two parameters apical and basilar spine density in parietal cortex demonstrating sex-dependent modification. These early changes in anatomy and behavior have important implications for later plasticity and long-term well-being. Synapse 66:950954, 2012. (C) 2012 Wiley Periodicals, Inc.