In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats.
In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats.
复制标题
胰岛素样生长因子-I (IGF-I) 对大鼠骨形成和吸收的体内作用。
DOI：
10.1016/8756-3282(91)90050-s
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发表时间：
1991
期刊：
影响因子：
4.1
通讯作者：
Howard,GA
中科院分区：
文献类型：
--
作者：
Spencer,EM;Liu,CC;Si,EC;Howard,GA
用一种新的模型研究了胰岛素样生长因子-I在体内对骨代谢的作用。将胰岛素样生长因子-I(IGF-I)持续注入活动大鼠右后肢动脉14d，用组织形态计量学方法检测其对皮质和松质骨形成及破骨细胞数量的影响。对侧肢体作为内对照。IGF-I输注显著增加皮质骨形成(p<；0.01)。骨小梁增加22%(p=0.07)，但仅用药7天。IGF-I的这些影响是年龄相关的，在年轻的、快速生长的动物中不存在，但至少存在到一岁。IGF-I似乎是一种纯粹的骨形成合成代谢激素，因为它显著刺激成骨细胞并减少破骨细胞的数量。因此，虽然IGF-I介导了生长激素的促生长作用，但它并不介导生长激素对骨吸收的作用。
The in vivo action of insulin-like growth factor-I on bone metabolism has been studied using a new model. Insulin-like growth factor-I (IGF-I) was continuously infused into the arterial supply of the right hindlimb of ambulatory rats for up to 14 days and the effects on cortical and trabecular bone formation and the number of osteoclasts were determined by histomorphometric techniques. The contralateral limb acted as an internal control. IGF-I infusion significantly increased cortical bone formation (p< 0.01). Trabecular bone was increased 22% (p= 0.07), but the infusion was only for seven days. These effects of IGF-I were age dependent, being absent in young, rapidly growing animals, but present at least until one year of age. IGF-I appears to be a purely anabolic hormone for bone formation, since it significantly stimulates osteoblasts and decreases the number of osteoclasts. Thus, although IGF-I mediates the growth-promoting effect of growth hormone, it does not mediate growth hormone's action on bone resorption.