The effects of aging and hearing loss on distortion product otoacoustic emissions.
The effects of aging and hearing loss on distortion product otoacoustic emissions.
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衰老和听力损失对失真产物耳声发射的影响。
DOI：
10.1016/s0194-59980300637-5
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Gates,GeorgeA
中科院分区：
文献类型：
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作者：
Cilento,BenjaminW;Norton,SusanJ;Gates,GeorgeA
目的：我们试图证明失真产物耳声发射（DPOE）振幅与年龄的变化率在听力损失的相关性在一个成年population.Study设计和设置：我们进行了一项横断面观察研究，涉及Fragrance后代队列。年龄变化的频率为f2从1到8 kHz调整纯音阈值level.Results：妇女的DPOE振幅的平均听力阈值调整损失的高频DPOE振幅为0.6，2.1，2.6，和1.1分贝/每十年在f2频率为1，2，4，和8 kHz，分别进行了评估。与此相反，男性的DPOE振幅没有表现出年龄的影响独立于听力损失。噪声陷波频率中的发射减少或不存在。在男性和女性中，DPOE振幅随年龄的变化率显著小于纯音听阈的变化率。结论：女性的DPOE振幅随着年龄的增长和听阈的降低而降低。男性的DPOE振幅损失比女性多，并且损失与听力阈值灵敏度的损失程度成正比。年龄相关性听力损失影响阈值超过排放量的差异效应表明，耳蜗萎缩可能是一个病理生理factor.SIGNIFICANCE：使用DPOE措施的筛选和监测成年女性的耳蜗状态应考虑到年龄，纯音阈值，和噪声暴露状态的科目。（耳鼻咽喉头颈外科2003;129：382-9。）
OBJECTIVE:We sought to demonstrate the rate of change in distortion product otoacoustic emission (DPOE) amplitude with age in relation to hearing loss in an unselected adult population.STUDY DESIGN AND SETTING:We conducted a cross-sectional observation study involving the Framingham Offspring Cohort. Age changes in DPOE amplitude for frequencies of f2 from 1 to 8 kHz adjusted for pure-tone threshold level were assessed by multivariate linear regression.RESULTS:The women showed a mean hearing threshold-adjusted loss in high-frequency DPOE amplitude of 0.6, 2.1, 2.6, and 1.1 dB/per decade at the f2 frequencies of 1, 2, 4, and 8 kHz, respectively. In contrast, the men showed no effect of age on the DPOE amplitude independent of hearing loss. Emissions were reduced or absent in the noise notch frequencies. The rate of change with age in DPOE amplitude was significantly less than the rate of change in pure-tone thresholds in both the men and the women.CONCLUSION:Women lose DPOE amplitude from both age and hearing threshold loss. Men lose more DPOE amplitude than do women, and the loss is proportional to the degree of loss of hearing threshold sensitivity. The differential effect whereby age-related hearing loss affects thresholds more than emissions suggests that strial atrophy may be a pathophysiologic factor.SIGNIFICANCE:The use of DPOE measures for screening and monitoring cochlear status of adult women should take into account the age, pure-tone thresholds, and noise exposure status of the subjects. (Otolaryngol Head Neck Surg 2003;129:382–9.)