Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing
Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing
复制标题
周期性强迫存在下细胞周期持续时间的遗传
DOI：
10.1103/physrevx.8.021035
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发表时间：
2018
影响因子：
12.5
通讯作者：
N. Balaban
中科院分区：
文献类型：
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作者：
Noga Mosheiff;Bruno M. C. Martins;Sivan Pearl;A. Grünberger;Stefan Helfrich;I. Mihalcescu;D. Kohlheyer;James C. W. Locke;L. Glass;N. Balaban
非线性振子的周期性强迫导致了大量的动力学行为。细胞周期与生物钟的耦合提供了这种强迫的生物学实现。使用高通量单细胞显微镜，我们已经研究了细胞周期持续时间之间的相关性，在离散谱系的几种不同的生物体，包括那些已知的耦合到一个昼夜节律钟和那些没有已知的耦合到一个昼夜节律钟。在具有生物钟的生物体中观察到的离散谱系中细胞周期持续时间之间的相关性不能用简单的统计模型来解释，但与生物学上合理的二维非线性映射的预测一致。令人惊讶的是，非线性映射等价于一个经典的非线性映射，称为胖阿诺德映射。该模型预测，昼夜节律耦合可能会增加细胞克隆群体中细胞间的变异性。与这一预测一致，生物钟的删除减少了变异性。我们的研究结果表明，简单的相关性可以识别系统的周期性强迫和非线性耦合的生物振荡器的研究提供了深入了解基本的细胞生长过程。
Periodic forcing of nonlinear oscillators leads to a large number of dynamic behaviors. The coupling of the cell-cycle to the circadian clock provides a biological realization of such forcing. Using high throughput single-cell microscopy, we have studied the correlations between cell cycle duration in discrete lineages of several different organisms including those with known coupling to a circadian clock and those without known coupling to a circadian clock. Correlations between cell cycles duration in discrete lineages observed in the organisms with a circadian clock cannot be explained by a simple statistical model but are consistent with predictions of a biologically plausible two dimensional nonlinear map. Surprisingly, the nonlinear map is equivalent to a classic nonlinear map called the fattened Arnold map. The model predicts that circadian coupling may increase cell to cell variability in a clonal population of cells. In agreement with this prediction, deletion of the circadian clock reduces variability. Our results show that simple correlations can identify systems under periodic forcing and that studies of nonlinear coupling of biological oscillators provide insight into basic cellular processes of growth.
DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
L. C. L. Palmer-L.-C.-L.-Palmer-2245994539;J. M. Cotton;Henley;Y Zheng;J. Mellem;P. J. Brockie;D. M. Madsen;Y Stern-Bach;S. Russo;M. Neuman;Christian Rosenmund;N Pilpel;N. Landeck;M. Klugmann;P. Seeburg;M. K. Schwarz;K M Partin;M. W. Fleck;M. L. Mayer;A Robert;N. Armstrong;J. Gouaux;J. R. Howe;M C Weston;C. Gertler;R. Hinz-Herkommer;I. Preugschat-Gumprecht;R. Zilberstein;Y. S. B. Sfb;Nationales Genomforschungsnetz;Max Planck Society;P. H. S. The;Qiong Yang;B. Pando;Guogang Dong;S. Golden;A. van Oudenaarden
通讯作者：
L. C. L. Palmer-L.-C.-L.-Palmer-2245994539;J. M. Cotton;Henley;Y Zheng;J. Mellem;P. J. Brockie;D. M. Madsen;Y Stern-Bach;S. Russo;M. Neuman;Christian Rosenmund;N Pilpel;N. Landeck;M. Klugmann;P. Seeburg;M. K. Schwarz;K M Partin;M. W. Fleck;M. L. Mayer;A Robert;N. Armstrong;J. Gouaux;J. R. Howe;M C Weston;C. Gertler;R. Hinz-Herkommer;I. Preugschat-Gumprecht;R. Zilberstein;Y. S. B. Sfb;Nationales Genomforschungsnetz;Max Planck Society;P. H. S. The;Qiong Yang;B. Pando;Guogang Dong;S. Golden;A. van Oudenaarden
DOI：
10.1073/pnas.93.19.10183
发表时间：
1996-09-17
影响因子：
11.1
作者：
Mori, T;Binder, B;Johnson, CH
通讯作者：
Johnson, CH