Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors.
Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors.
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DOI：
10.1038/nrm.2016.122
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Hammes SR
中科院分区：
文献类型：
--
作者：
Levin ER;Hammes SR
类固醇激素受体介导了许多重要的生物过程，并被经典地认为是在细胞核中起转录调节作用。然而，50多年来人们已经知道，类固醇在许多器官中引起快速反应，这无法用基因调控来解释。越来越多的证据表明，大多数类固醇受体实际上存在于核外细胞池中，包括质膜。当类固醇配体参与后，后者迅速激活影响细胞生物学各个方面的信号。对核外类固醇受体池诱导的信号传导机制的研究，以及这种核外信号传导如何与核受体池引发的反应相结合，为类固醇激素信号传导及其在健康和疾病中的作用提供了新的认识。
Steroid hormone receptors mediate numerous crucial biological processes and are classically thought to function as transcriptional regulators in the nucleus. However, it has been known for more than 50 years that steroids evoke rapid responses in many organs that cannot be explained by gene regulation. Mounting evidence indicates that most steroid receptors in fact exist in extranuclear cellular pools, including at the plasma membrane. This latter pool, when engaged by a steroid ligand, rapidly activates signals that affect various aspects of cellular biology. Research into the mechanisms of signalling instigated by extranuclear steroid receptor pools and how this extranuclear signalling is integrated with responses elicited by nuclear receptor pools provides novel understanding of steroid hormone signalling and its roles in health and disease.
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影响因子：
64.5
作者：
Han SJ;Jung SY;Wu SP;Hawkins SM;Park MJ;Kyo S;Qin J;Lydon JP;Tsai SY;Tsai MJ;DeMayo FJ;O'Malley BW
通讯作者：
O'Malley BW
影响因子：
5.3
作者：
Bhatt, Shweta;Xiao, Zhen;Katzenellenbogen, Benita S.
通讯作者：
Katzenellenbogen, Benita S.
影响因子：
15.9
作者：
Chen, Z;Yuhanna, IS;Shaul, PW
通讯作者：
Shaul, PW
影响因子：
3.3
作者：
Acconcia, F;Ascenzi, P;Marino, M
通讯作者：
Marino, M
DOI：
10.2165/00129785-200404010-00003
发表时间：
2004-01-01
期刊：
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice
影响因子：
--
作者：
Barkhem, Tomas;Nilsson, Stefan;Gustafsson, Jan-Ake
通讯作者：
Gustafsson, Jan-Ake