Neurotrophins and psychiatric disorders.
Neurotrophins and psychiatric disorders.
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DOI：
10.1007/978-3-642-45106-5_17
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Castren, E
中科院分区：
文献类型：
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作者：
Castren, E
在过去十年中，越来越多的研究将神经营养因子与神经精神疾病的病理生理学以及用于治疗这些疾病的药物的作用机制联系起来。特别是，脑源性神经营养因子BDNF及其受体TrkB与情绪障碍的病理生理有关，并且有强有力的证据表明，BDNF信号通路通过药理学和心理手段在抑郁症的康复中起着关键作用。神经营养因子在发育中的成人大脑的神经元可塑性和网络连接中起着核心作用，最近的证据表明可塑性和网络重新连接与情绪障碍及其治疗有关。因此，神经营养素不应被视为快乐因素，而应被视为大脑网络对环境进行最佳调整过程中的关键工具。正是在这种背景下，我们应该研究神经营养素对神经精神疾病的影响。
Increasing number of studies has during the last decade linked neurotrophic factors with the pathophysiology of neuropsychiatric disorders and with the mechanisms of action of drugs used for the treatment of these disorders. In particular, brain-derived neurotrophic factor BDNF and its receptor TrkB have been connected with the pathophysiology in mood disorders, and there is strong evidence that BDNF signaling is critically involved in the recovery from depression with both pharmacological and psychological means. Neurotrophins play a central role in neuronal plasticity and network connectivity in developing adult brain, and recent evidence links plasticity and network rewiring with mood disorders and their treatment. Therefore, neurotrophins should not be seen as happiness factors but as critical tools in the process where brain networks are optimally tuned to environment, and it is against this background that the effects of neurotrophins on neuropsychiatric disorders should be looked at.