Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit.
Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit.
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小鼠神经嵴中 Tbx3 的缺失会减少肠神经胶质细胞并导致腭裂，但不会影响心脏发育或肠道运输。
DOI：
10.1016/j.ydbio.2018.09.017
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发表时间：
2018
影响因子：
2.7
通讯作者：
Heuckeroth,RobertO
中科院分区：
文献类型：
--
作者：
López,SilviaHuerta;Avetisyan,Marina;Wright,ChristinaM;Mesbah,Karim;Kelly,RobertG;Moon,AnneM;Heuckeroth,RobertO
Transcription factors that coordinate migration, differentiation or proliferation of enteric nervous system (ENS) precursors are not well defined. To identify novel transcriptional regulators of ENS development, we performed microarray analysis at embryonic day (E) 17.5 and identified many genes that were enriched in the ENS compared to other bowel cells. We decided to investigate the T-box transcription factorTbx3, which is prominently expressed in developing and mature ENS. Haploinsufficiency forTBX3causes ulnar-mammary syndrome (UMS) in humans, a multi-organ system disorder. TBX3 also regulates several genes known to be important for ENS development. To test the hypothesis thatTbx3is important for ENS development or function, we inactivatedTbx3in all neural crest derivatives, including ENS progenitors usingWnt1-Creand a floxedTbx3allele.Tbx3 fl/fl; Wnt1-Creconditional mutant mice die shortly after birth with cleft palate and difficulty feeding. The ENS of mutants was well-organized with a normal density of enteric neurons and nerve fiber bundles, but small bowel glial cell density was reduced. Despite this, bowel motility appeared normal. Furthermore, althoughTbx3is expressed in cardiac neural crest,Tbx3 fl/fl; Wnt1-Cremice had structurally normal hearts. Thus, loss ofTbx3within neural crest has selective effects onTbx3-expressing neural crest derivatives.
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影响因子：
15.9
作者：
Puig, Isabel;Champeval, Delphine;Larue, Lionel
通讯作者：
Larue, Lionel
影响因子：
2.7
作者：
Fu, Ming;Vohra, Bhupinder P. S.;Heuckeroth, Robert O.
通讯作者：
Heuckeroth, Robert O.
DOI：
10.1007/s00018-011-0884-2
发表时间：
2011-12
期刊：
Cellular and Molecular Life Sciences: CMLS
影响因子：
--
作者：
Reena Singh;W. Hoogaars;P. Barnett;Thomas Grieskamp;M. Rana;H. Buermans;H. Farin;M. Petry;Todd R. Heallen;James F. Martin;A. Moorman;Peter A. C. ‘t Hoen;A. Kispert;V. Christoffels
通讯作者：
Reena Singh;W. Hoogaars;P. Barnett;Thomas Grieskamp;M. Rana;H. Buermans;H. Farin;M. Petry;Todd R. Heallen;James F. Martin;A. Moorman;Peter A. C. ‘t Hoen;A. Kispert;V. Christoffels
影响因子：
11.8
作者：
Osterwalder, Marco;Speziale, Dario;Shoukry, Malak;Mohan, Rajiv;Ivanek, Robert;Kohler, Manuel;Beisel, Christian;Wen, Xiaohui;Scales, Suzie J.;Christoffels, Vincent M.;Visel, Axel;Lopez-Rios, Javier;Zeller, Rolf
通讯作者：
Zeller, Rolf
影响因子：
15.9
作者：
Lake, Jonathan I.;Tusheva, Olga A.;Heuckeroth, Robert O.
通讯作者：
Heuckeroth, Robert O.