Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
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DOI：
10.1093/gerona/glr223
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发表时间：
2012-04-01
影响因子：
5.1
通讯作者：
Perls, Thomas T.
中科院分区：
文献类型：
--
作者：
Andersen, Stacy L.;Sebastiani, Paola;Perls, Thomas T.
我们分析了百岁老人（年龄100-104岁），半超百岁老人（年龄105-109岁）和超百岁老人（年龄110-119岁）之间的生存年龄，发病率和残疾之间的关系。对104名超级百岁老人、430名半超级百岁老人、884名百岁老人、343名90岁老人和436名对照者进行了平均3年（范围0-13年）的前瞻性随访。一般来说，年龄组越大，癌症、心血管疾病、痴呆和中风等疾病以及认知和功能下降的发病越晚。随着年龄的增长，这些疾病的风险比逐渐降低，随着年龄的增长，患病的相对时间也越来越短。我们观察到随着年龄的增长，身体和认知功能障碍、年龄相关疾病和总体发病率的发病年龄逐渐延迟。随着超百岁老人有效地接近人类寿命的极限，普遍观察到发病率的压缩。
We analyze the relationship between age of survival, morbidity, and disability among centenarians (age 100-104 years), semisupercentenarians (age 105-109 years), and supercentenarians (age 110-119 years). One hundred and four supercentenarians, 430 semisupercentenarians, 884 centenarians, 343 nonagenarians, and 436 controls were prospectively followed for an average of 3 years (range 0-13 years). The older the age group, generally, the later the onset of diseases, such as cancer, cardiovascular disease, dementia, and stroke, as well as of cognitive and functional decline. The hazard ratios for these individual diseases became progressively less with older and older age, and the relative period of time spent with disease was lower with increasing age group. We observed a progressive delay in the age of onset of physical and cognitive function impairment, age-related diseases, and overall morbidity with increasing age. As the limit of human life span was effectively approached with supercentenarians, compression of morbidity was generally observed.