Potential Role of Soluble Toll-like Receptors 2 and 4 as Therapeutic Agents in Stroke and Brain Hemorrhage.
Potential Role of Soluble Toll-like Receptors 2 and 4 as Therapeutic Agents in Stroke and Brain Hemorrhage.
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DOI：
10.3390/ijms22189977
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发表时间：
2021-09-15
影响因子：
5.6
通讯作者：
Doré S
中科院分区：
文献类型：
--
作者：
Lua J;Ekanayake K;Fangman M;Doré S
溶血是一种生理状态，其中红细胞（rbc）溶解，释放其内容物到细胞外环境。溶血可能是多种疾病的表现，如镰状细胞病、出血性中风和创伤。血红素和血红蛋白是红细胞释放到环境中的独特成分。虽然这些内容物可以引起氧化应激，特别是当在细胞外环境中被氧化时，它们也可以启动促炎反应，因为它们与toll样受体（TLR）家族等受体结合。本文旨在阐明TLRs对血红素、血红蛋白及其氧化衍生物启动促炎反应的机制，以及使用可溶性TLRs （stlr）作为治疗剂的可能性。此外，本综述探讨了在出血性疾病（包括出血性卒中及其亚型、脑出血（ICH）和蛛网膜下腔出血（SAH））中使用stlr的可能性，其中减轻炎症对临床结果至关重要。
Hemolysis is a physiological condition in which red blood cells (RBCs) lyse, releasing their contents into the extracellular environment. Hemolysis can be a manifestation of several diseases and conditions, such as sickle cell disease, hemorrhagic stroke, and trauma. Heme and hemoglobin are among the unique contents of RBCs that are released into the environment. Although these contents can cause oxidative stress, especially when oxidized in the extracellular environment, they can also initiate a proinflammatory response because they bind to receptors such as the Toll-like receptor (TLR) family. This review seeks to clarify the mechanism by which TLRs initiate a proinflammatory response to heme, hemoglobin, and their oxidized derivatives, as well as the possibility of using soluble TLRs (sTLRs) as therapeutic agents. Furthermore, this review explores the possibility of using sTLRs in hemorrhagic disorders in which mitigating inflammation is essential for clinical outcomes, including hemorrhagic stroke and its subtypes, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).
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TAK-242 是 Toll 样受体 4 的拮抗剂，可预防小鼠急性脑缺血/再灌注损伤。
DOI：
10.1038/jcbfm.2014.240
发表时间：
2015-03-31
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.3
作者：
Foresti, Roberta;Bains, Sandip K.;Motterlini, Roberto
通讯作者：
Motterlini, Roberto
影响因子：
4.4
作者：
Iwami, K;Matsuguchi, T;Yoshikai, Y
通讯作者：
Yoshikai, Y
DOI：
10.1602/neurorx.2.4.554
发表时间：
2005-10-01
期刊：
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Alavijeh, Mohammad S;Chishty, Mansoor;Palmer, Alan M
通讯作者：
Palmer, Alan M
血红素加氧酶-1通过TLR2/TLR4触发的信号通路保护大鼠肝脏免受热缺血/再灌注损伤
影响因子：
4.3
作者：
Huang, Han-Fei;Zeng, Zhong;Duan, Jian
通讯作者：
Duan, Jian