Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms.
Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms.
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DOI：
10.1176/foc.8.4.foc647
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发表时间：
2010-10
期刊：
影响因子：
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通讯作者：
Keizo Yoshida;Hitoshi Takahashi;H. Higuchi;M. Kamata;Kenich Ito;Kazuhiro Sato;Shingo Naito;T. Shimizu;K. Itoh;K. Inoue;Toshio Suzuki;C. Nemeroff
中科院分区：
文献类型：
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作者：
Keizo Yoshida;Hitoshi Takahashi;H. Higuchi;M. Kamata;Kenich Ito;Kazuhiro Sato;Shingo Naito;T. Shimizu;K. Itoh;K. Inoue;Toshio Suzuki;C. Nemeroff
目的：随着抗抑郁药物的大量可用，对不同类别抗抑郁药物的反应预测因素具有相当大的兴趣。本研究的目的是确定去甲肾上腺素转运基因（NET）和5-羟色胺转运基因（5-HTT）多态性是否与对milnacpran（一种双血清素/去甲肾上腺素再摄取抑制剂）的抗抑郁反应有关。方法96例日本重度抑郁症患者采用米那西普兰（50 ~ 100 mg/d）治疗，疗程6周。抑郁症的严重程度用蒙哥马利-阿斯伯格抑郁症评定量表进行评估。在基线和治疗1、2、4和6周时进行评估。采用聚合酶链反应法测定等位基因变异。结果：80例患者完成了研究。NET T- 182c多态性的T等位基因的存在与较好的抗抑郁反应相关，而NET G1287A多态性的a / a基因型与较慢的治疗反应相关。相比之下，没有检测到5-HTT多态性对milnacpran抗抑郁反应的影响。结论：NET多态性而非5-HTT多态性在一定程度上决定了百纳西普兰的抗抑郁反应。
OBJECTIVE With a multitude of antidepressants available, predictors of response to different classes of antidepressants are of considerable interest. The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual serotonin/norepinephrine reuptake inhibitor. METHOD Ninety-six Japanese patients with major depressive disorder were treated with milnacipran, 50-100 mg/day, for 6 weeks. Severity of depression was assessed with the Montgomery-Asberg Depression Rating Scale. Assessments were carried out at baseline and at 1, 2, 4, and 6 weeks of treatment. The method of polymerase chain reaction was used to determine allelic variants. RESULTS Eighty patients completed the study. The presence of the T allele of the NET T-182C polymorphism was associated with a superior antidepressant response, whereas the A/A genotype of the NET G1287A polymorphism was associated with a slower onset of therapeutic response. In contrast, no influence of 5-HTT polymorphisms on the antidepressant response to milnacipran was detected. CONCLUSIONS The results suggest that NET but not 5-HTT polymorphisms in part determine the antidepressant response to milnacipran.