An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials
An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials
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DOI：
10.1021/jacs.9b10770
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发表时间：
2020-01-08
影响因子：
15
通讯作者：
Spokoyny, Alexander M.
中科院分区：
文献类型：
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作者：
Stauber, Julia M.;Qian, Elaine A.;Spokoyny, Alexander M.
几十年来，化学家们一直致力于通过可编程无机纳米材料的生物启发合成来模仿自然发生系统的复杂设计和多种功能。硫醇封端的金纳米颗粒（AuNPs）的发展推动了这一领域的进步;然而，尽管用途广泛且易于获得，但混合AuNPs很少具有原子级精确性，这限制了对其表面拓扑结构的控制，因此限制了复杂结构-功能关系的研究。在这里，我们提出了一个自下而上的方法，原子级精确的混合纳米团簇的系统组装采用的策略，模仿的合成容易与硫醇封端的金纳米粒子通常构建，同时产生定义良好的共价纳米级组件与不同的表面拓扑结构。第一次，使用结构特征的基于簇的有机金属构建块，我们展示了系统的合成具有多价结合能力的纳米簇，以复杂的蛋白质目标。
For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.