Positive association of serum levels of advanced glycation end products with thrombogenic markers in humans
Positive association of serum levels of advanced glycation end products with thrombogenic markers in humans
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DOI：
10.1016/j.metabol.2006.02.019
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发表时间：
2006-07-01
影响因子：
9.8
通讯作者：
Imaizumi, Tsutomu
中科院分区：
文献类型：
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作者：
Enomoto, Mika;Adachi, Hisashi;Imaizumi, Tsutomu
晚期糖基化终末产物（AGEs）在糖尿病中升高。我们已经证明，AGEs触发血栓形成的反应，在培养的细胞。我们在这里研究了血清AGE水平是否与人类血栓形成标志物正相关。从日本一般人群中获得186例非糖尿病受试者的空腹血清AGE水平数据。我们测量了体重指数、血压、总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇、甘油三酯、空腹血糖、糖化血红蛋白A（1c）、胰岛素、肌酐、尿酸、高敏C反应蛋白、纤溶酶原激活物抑制剂1（派-1）和纤维蛋白原。对血清AGE水平的决定因素进行单因素和多因素分析。男性的平均AGE水平为4.11 +/- 0.74 U/mL，女性为4.10 +/- 0.93 U/mL。在单因素分析中，派-1（P
Advanced glycation end products (AGEs) are elevated in diabetes. We have demonstrated that AGEs trigger thrombogenic responses in cultured cells. We investigated here whether serum AGE levels were positively correlated with thrombogenic markers in humans. Data for fasting serum AGE levels of 186 nondiabetic subjects were obtained from a general population in Japan. We measured body mass index, blood pressure, total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol, triglycerides, fasting plasma glucose, glycosylated hemoglobin A(1c), insulin, creatinine, uric acid, high-sensitive C-reactive protein, plasminogen activator inhibitor 1 (PAI-1), and fibrinogen. Uni- and multivariate analyses were applied for the determinants of serum AGE levels. The average AGE levels were 4.11 +/- 0.74 U/mL in males and 4.10 +/- 0.93 U/mL in females. In the univariate analysis, PAI-1 (P