Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia
Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia
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DOI：
10.2217/rme.13.87
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Christiano, Angela M.
中科院分区：
文献类型：
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作者：
Higgins, Claire A.;Christiano, Angela M.
目前治疗雄激素性脱发的许多药物疗法都是偶然发现的，当药物用于治疗不同的疾病时，毛发生长被观察到是一种偏离目标的效应。随后，几项使用培养细胞的研究已经能够鉴定出与目前可用的药物具有类似性质的毛发生长调节剂，这也可能提供临床益处。在目前的治疗方法不起作用的情况下，卵泡单位移植是一种替代的手术选择。最近，毛囊细胞移植或毛囊新生的概念被尝试，利用培养的毛囊细胞的固有特性来诱导秃顶头皮的新生毛发生长。在这篇综述中，除了详细介绍毛囊细胞植入的现有知识外，我们还讨论了细胞培养技术的进展，这些技术已经导致了促进头发生长的更广泛的潜在疗法，以及使这种方法成为现实的挑战。
Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar properties to the currently available drugs, which may also provide clinical benefit. In situations where the current therapeutics do not work, follicular unit transplantation is an alternative surgical option. More recently, the concept of follicular cell implantation, or hair follicle neogenesis, has been attempted, exploiting the inherent properties of cultured hair follicle cells to induce de novo hair growth in balding scalp. In this review, we discuss both the advances in cell culture techniques that have led to a wider range of potential therapeutics to promote hair growth, in addition to detailing current knowledge on follicular cell implantation, and the challenges in making this approach a reality.