The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice.
The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice.
复制标题
朝鲜红人人参提取物对饮食诱导的肥胖小鼠葡萄糖调节的改善的影响。
DOI：
10.1016/j.jgr.2015.12.011
复制
发表时间：
2017-01
影响因子：
6.3
通讯作者：
Kim DH
中科院分区：
文献类型：
--
作者：
Oh MJ;Kim HJ;Park EY;Ha NH;Song MG;Choi SH;Chun BG;Kim DH
韩国红参提取物（KRG，Panax ginseng Meyer）及其成分已用于治疗糖尿病。然而，在饮食诱导的肥胖小鼠中，尚不清楚KRG是否能增强罗格列酮（ROSI）的降糖作用，ROSI是一种过氧化物酶体增殖物激活受体γ合成激活剂。口服葡萄糖耐量试验（oGTT）在用媒介物（CON）、KRG [500 mg/kg体重（b.w.）]、ROSI（3.75 mg/kg B. w、7.5 mg/kg B. w和15 mg/kg b.w.），或ROSI和KRG（RK）。通过苏木精-伊红染色或定量逆转录聚合酶链反应比较脂肪组织形态、冠状结构（CLS）和炎症。RK组的葡萄糖曲线下面积（AUC）显著较低（15 mg/kg b.w.和500 mg/kg b.w. ROSI和KRG）比CON组。CON组与其他组之间的AUC无显著差异。此外，RK组的AUC显著低于ROSI组。与CON组相比，RK组Ccl2基因的表达和CLS的数量显著减少。我们的研究结果表明，通过与KRG联合治疗，ROSI诱导的葡萄糖调节改善可能得到增强。
Korean Red Ginseng extract (KRG, Panax ginseng Meyer) and its constituents have been used for treating diabetes. However, in diet-induced obese mice, it is unclear whether KRG can enhance the glucose-lowering action of rosiglitazone (ROSI), a peroxisome proliferator-activated receptor gamma synthetic activator. Oral glucose tolerance tests (oGTTs) were performed after 4 days of treatment with a vehicle (CON), KRG [500 mg/kg body weight (b.w.)], ROSI (3.75 mg/kg b.w, 7.5 mg/kg b.w, and 15 mg/kg b.w.), or ROSI and KRG (RK) in obese mice on a high-fat diet. Adipose tissue morphology, crown-like structures (CLSs), and inflammation were compared by hematoxylin-eosin staining or quantitative reverse transcription polymerase chain reaction. The area under the glucose curve (AUC) was significantly lower in the RK group (15 mg/kg b.w. and 500 mg/kg b.w. for ROSI and KRG, respectively) than in the CON group. There was no significant difference in the AUC between the CON and the other groups. Furthermore, the AUC was significantly lower in the RK group than in the ROSI group. The expression of the Ccl2 gene and the number of CLSs were significantly reduced in the RK group than in the CON group. Our results show a potential enhancement of ROSI-induced improvement of glucose regulation by the combined treatment with KRG.