Concise reviews: In vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.
Concise reviews: In vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.
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DOI：
10.1002/stem.1828
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发表时间：
2015-01
期刊：
影响因子：
5.2
通讯作者：
Grapin-Botton, Anne
中科院分区：
文献类型：
--
作者：
Greggio, Chiara;De Franceschi, Filippo;Grapin-Botton, Anne
器官生物发生的三维模型最近蓬勃发展。它们促进干/祖细胞扩增和分化之间的平衡，而不受扁平组织培养容器的限制，允许细胞的自主自组织。这种模型允许在培养皿中形成微型器官，并且正在从胚胎祖细胞和成体细胞开始出现胰腺。这篇评论的重点是目前可用的系统，以及这些系统如何允许新类型的问题得到解决。我们讨论了预期的进展，包括它们在研究人类胰腺发育和功能以及开发糖尿病模型和治疗细胞方面的潜力。
Three dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focusses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells.
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影响因子：
64.8
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64.8
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影响因子：
29.4
作者：
Houbracken, Isabelle;de Waele, Evelien;Bouwens, Luc
通讯作者：
Bouwens, Luc
影响因子：
64.8
作者：
Dor, Y;Brown, J;Melton, DA
通讯作者：
Melton, DA
影响因子：
8.2
作者：
Baeyens, L;De Breuck, S;Bouwens, L
通讯作者：
Bouwens, L