PHOTODYNAMIC INACTIVATION OF SARCOPLASMIC RETICULUM VESICLE MEMBRANES BY XANTHENE DYES
PHOTODYNAMIC INACTIVATION OF SARCOPLASMIC RETICULUM VESICLE MEMBRANES BY XANTHENE DYES
复制标题
呫吨染料对肌质网囊泡膜的光动力灭活
DOI：
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发表时间：
1974
影响因子：
3.3
通讯作者：
M. Kasai
中科院分区：
文献类型：
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作者：
M. Kondo;M. Kasai
摘要：研究了一系列氧杂蒽染料对肌浆网（SR）囊泡膜的光敏氧化作用。随着染料浓度的增加和光照时间的延长，SR的钙离子吸收率、ATP酶活性和紫外荧光强度降低，241 nm处的吸光度增加。在氧杂蒽染料中，SR的钙摄取和ATP酶活性的失活顺序与241 nm处的荧光强度的降低和吸光度的增加的顺序雅阁。氧杂蒽染料的分子结构与SR膜的光动力学失活之间存在着一定的规律性关系。
Abstract— Photosensitized oxidation of sarcoplasmic reticulum (SR) vesicle membranes by a series of xanthene dyes was investigated. With increasing dye concentration and illumination time, the calcium ion uptake, ATPase activity and UV fluorescence intensity of SR decreased, and the absorbance at 241 nm increased. In xanthene dyes, the order of inactivation of the calcium uptake and ATPase activity of SR was in accord with decreasing order, of fluorescence intensity and increasing order of absorbance at 241 nm. Some regular relationships exist between the molecular structures of xanthene dyes and the photodynamic inactivation of SR membranes.