AGE DISTRIBUTION OF HISTOLOGIC TYPES OF BREAST-CARCINOMA
AGE DISTRIBUTION OF HISTOLOGIC TYPES OF BREAST-CARCINOMA
复制标题
DOI：
10.1002/ijc.2910540102
复制
发表时间：
1993-04-22
影响因子：
6.4
通讯作者：
THOMAS, DB
中科院分区：
文献类型：
--
作者：
STALSBERG, H;THOMAS, DB
美国国家癌症研究所监测、流行病学和最终结果（SEER）项目中的大量病例允许对浸润性乳腺癌组织学类型的年龄分布进行详细分析。在50至85岁的女性中，髓样癌、炎性癌和大汗腺癌的年龄特异性发病率几乎没有变化;佩吉特病以及导管癌、小叶癌、管状癌和化生癌的发病率约为绝经期发病率的两倍;粘液癌、乳头状癌和印戒细胞癌的发病率增至绝经期发病率的4至8倍。年龄-发病率曲线上的围绝经期突变在主要起源于小叶的癌中最明显，而在主要起源于导管的癌中几乎不存在。在男性中，乳头状癌的年龄分布与所有类型合并的年龄分布相似，而粘液癌的年龄分布与女性一样偏向于老年。
The large number of cases in the Surveillance, Epidemiology and End Results (SEER) program of the US National Cancer Institute allowed a detailed analysis of the age distribution of the histologic types of invasive breast carcinoma. Between ages 50 and 85 years in females, the age-specific incidence rate shows little change for medullary, inflammatory and apocrine carcinomas; is about doubled for Paget's disease and for ductal, lobular, tubular and metaplastic carcinomas; and increases to 4 to 8 times the menopausal level for mucinous, papillary and signet-ring-cell carcinomas. The peri-menopausal break on the age-incidence curve is most marked for carcinomas of predominantly lobular origin and virtually absent for carcinomas Of predominantly ductal origin. In males, the age distribution of papillary carcinoma is similar to that of all types combined, whereas that of mucinous carcinoma is skewed towards older ages, as in females.