Perplexing effects of hippocampal lesions on latent inhibition: A neural network solution
Perplexing effects of hippocampal lesions on latent inhibition: A neural network solution
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DOI：
10.1037/0735-7044.112.2.316
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发表时间：
1998-04-01
影响因子：
1.9
通讯作者：
Schmajuk, NA
中科院分区：
文献类型：
--
作者：
Buhusi, CV;Gray, JA;Schmajuk, NA
实验数据表明，海马损伤可能会损害，备用，甚至促进潜伏抑制（LI）。此外，当LI受损的病变，它可能会恢复氟哌啶醇管理。本文应用经典条件反射的神经网络模型（N。A. Schmajuk，Y. W.林和JA Gray，1996）来研究这些令人困惑的结果的可能原因。根据该模型，LI的表现，因为预暴露的条件刺激（CS）减少新奇，定义为预测和观察到的事件之间的不匹配的总和成比例，从而减少注意CS和延迟条件。据推测，海马病变影响事件的预测。计算机模拟显示，根据行为协议（即，CS预暴露的程序和总时间），海马损伤动物的新奇可能大于、等于或小于（对应于更小、相等或更大的LI）。假设海马损伤后新奇增加时，多巴胺能拮抗剂降低了新奇值，从而解释了氟哌啶醇给药后LI的恢复。
Experimental data indicate that hippocampal lesions might impair, spare, or even facilitate latent inhibition (LI). Furthermore, when LI is impaired by the lesions, it might be reinstated by haloperidol administration. The present article applies a neural network model of classical conditioning (N. A. Schmajuk, Y. W. Lam, & J. A. Gray, 1996) to investigate the possible causes of these puzzling results. According to the model, LI is manifested because preexposure of the conditioned stimulus (CS) reduces Novelty, defined as proportional to the sum of the mismatches between predicted and observed events, thereby reducing attention to the CS and retarding conditioning. It is assumed that hippocampal lesions affect the prediction of events. Computer simulations reveal that, depending on the behavioral protocol (i.e., procedure and total time of CS preexposure), Novelty in hippocampal lesioned animals might be larger, equal, or smaller (corresponding to smaller, equal, or larger LI) than in normal controls. Reinstatement of LI by haloperidol administration is explained by assuming that dopaminergic antagonists decrease the value of Novelty, when Novelty increases following hippocampal lesions.