SSRI-associated nocturnal bruxism in four patients.
SSRI-associated nocturnal bruxism in four patients.
复制标题
四名患者出现 SSRI 相关的夜间磨牙症。
DOI：
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复制
发表时间：
1993
影响因子：
5.3
通讯作者：
P. Stanziani
中科院分区：
文献类型：
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作者：
James M. Ellison;P. Stanziani
背景
夜间磨牙症（睡眠期间咬牙和/或磨牙）影响很大一部分人口。其病因尚不清楚，也没有完全令人满意的治疗方法。
方法
这是一份对四名抑郁症患者的观察报告，这些患者是从一位城市医院精神药理学诊所的精神科医生的实践中选出的。精神科诊断根据DSM-III-R标准进行。夜间磨牙症是根据牙科检查和/或自我报告的夜间咬牙和/或磨牙情况确定的。
结果
4 名患者在开始氟西汀或舍曲林治疗后 2 至 4 周内出现夜间磨牙症。在减少抗抑郁药剂量（N = 1）或添加丁螺环酮（N = 3）后，所有患者的磨牙症均得到缓解。
结论
这些观察结果表明，选择性血清素再摄取抑制剂（SSRI）治疗与夜间磨牙症的发作或恶化之间存在关联，应通过对照研究予以证实。此外，他们认为减少 SSRI 剂量或添加丁螺环酮可能会缓解 SSRI 相关的夜间磨牙症。
BACKGROUND
Nocturnal bruxism (tooth clenching and/or grinding during sleep) affects a significant proportion of the population. Its etiology remains uncertain, and no entirely satisfactory treatment is available.
METHOD
This is an observational report of four depressed individuals selected from one psychiatrist's practice within an urban hospital's psychopharmacology clinic. Psychiatric diagnoses were made according to DSM-III-R criteria. Nocturnal bruxism was determined on the basis of dental examination and/or self-reported nocturnal tooth clenching and/or grinding.
RESULTS
Four patients developed nocturnal bruxism within 2 to 4 weeks after initiation of treatment with fluoxetine or sertraline. Bruxism remitted in all patients after a decrease in antidepressant dosage (N = 1) or addition of buspirone (N = 3).
CONCLUSION
These observations, which should be confirmed by a controlled study, suggest an association between serotonin selective reuptake inhibitor (SSRI) treatment and the onset or exacerbation of nocturnal bruxism. In addition, they suggest that a decrease in SSRI dosage or the addition of buspirone may relieve SSRI-associated nocturnal bruxism.